Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis.
Multi-center, Placebo-controlled, Double-blind, Randomized Study of Oral Toceranib Phosphate (SU11654), a Receptor Tyrosine Kinase Inhibitor, for the Treatment of Dogs with Recurrent (Either Local or…
Palladia has biological activity against canine MCTs and can be administered on a continuous schedule without need for routine planned treatment breaks, and shows that spontaneous tumors in dogs are good models to evaluate therapeutic index of targeted therapeutics in a clinical setting.
Phase I dose-escalating study of SU11654, a small molecule receptor tyrosine kinase inhibitor, in dogs with spontaneous malignancies.
This study provides the first evidence that p.o. administered kinase inhibitors can exhibit activity against a variety of spontaneous malignancies in dogs, and it is likely that such agents will demonstrate comparable antineoplastic activity in people.
Spontaneous canine mast cell tumors express tandem duplications in the proto-oncogene c-kit.
Feline lymphoma in the post-feline leukemia virus era.
- M. Louwerens, C. London, N. Pedersen, L. Lyons
- MedicineJournal of Veterinary Internal Medicine
- 1 May 2005
A significant decrease in the importance of FeLV-associated types of lymphoma in cats is confirmed and Associations of intestinal lymphoma and inflammatory bowel disease and diet should be further considered.
Prevalence and importance of internal tandem duplications in exons 11 and 12 of c-kit in mast cell tumors of dogs.
- S. Downing, May Chien, P. Kass, P. Moore, C. London
- Medicine, BiologyAmerican Journal of Veterinary Research
- 1 December 2002
Evidence is provided that ITDs in c-kit occur frequently in MCTs of dogs, providing an ideal naturally developing tumor in which to test the safety and efficacy of novel small-molecule kinase inhibitors such as imatinib mesylate.
Functional Responses and Costimulator Dependence of Memory CD4+ T Cells1
The findings suggest that the threshold for activation of memory CD4+ cells is lower than that of naive cells, which would permit memory cells to rapidly express their effector functions in vivo earlier in the course of a secondary immune response, when the levels of Ag and the availability of costimulation may be relatively low.
Canine osteosarcoma: a naturally occurring disease to inform pediatric oncology.
Clinical and molecular evidence suggests that human and canine OSA share many key features, including tumor location, presence of microscopic metastatic disease at diagnosis, development of chemotherapy-resistant metastases, and altered expression/activation of several proteins, supporting the notion that these diseases are similar at the molecular level.
Mitotic Index Is Predictive for Survival for Canine Cutaneous Mast Cell Tumors
- E. Romansik, C. Reilly, P. Kass, P. Moore, C. London
- MedicineVeterinary Pathology-Supplement
- 1 May 2007
Evaluating the utility of MI as a predictor of biologic behavior and survival in dogs with cutaneous mast cell tumors found it to be a strong predictor of overall survival and should be included as a prognostic indicator when determining therapeutic options.