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GRIN2B protein, human

Known as: N-Methyl-D-Aspartate Receptor Subunit 2B, NMDAR2B, hNR3 
Glutamate receptor ionotropic, NMDA 2B (1484 aa, ~166 kDa) is encoded by the human GRIN2B gene. This protein plays a role in both calcium transport… 
National Institutes of Health

Related topics

Related topics

24 relations
Alzheimer's Disease Pathway KEGGCellular MembraneERBB4 Signaling PathwayGRIN2B gene

Broader (1)

NMDA receptor 2B

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2017
Highly Cited
2017
Cryo-EM structures of the triheteromeric NMDA receptor and its allosteric modulation
Added complexity in an asymmetric receptor N-methyl-d-aspartate receptors (NMDARs) are heterotetrameric ion channels that… 
Highly Cited
2014
Highly Cited
2014
GluN2B-containing NMDA receptors regulate depression-like behavior and are critical for the rapid antidepressant actions of ketamine
A single, low dose of the NMDA receptor antagonist ketamine produces rapid antidepressant actions in treatment-resistant… 
Highly Cited
2013
Highly Cited
2013
Double Dissociation of the Requirement for GluN2B- and GluN2A-Containing NMDA Receptors in the Destabilization and Restabilization of a Reconsolidating Memory
Signaling at NMDA receptors (NMDARs) is known to be important for memory reconsolidation, but while most studies show that NMDAR… 
Highly Cited
2012
Highly Cited
2012
NMDA GluN2A and GluN2B receptors play separate roles in the induction of LTP and LTD in the amygdala and in the acquisition and extinction of conditioned fear
Highly Cited
2011
Highly Cited
2011
Subunit Arrangement and Phenylethanolamine Binding in GluN1/GluN2B NMDA Receptors
Since it was discovered that the anti-hypertensive agent ifenprodil has neuroprotective activity through its effects on NMDA (N… 
Review
2009
Review
2009
Allosteric modulators of NR2B‐containing NMDA receptors: molecular mechanisms and therapeutic potential
N‐methyl‐D‐aspartate receptors (NMDARs) are ion channels gated by glutamate, the major excitatory neurotransmitter in the… 
Highly Cited
2003
Highly Cited
2003
Pituitary Adenylate Cyclase-activating Polypeptide (PACAP(1–38)) Enhances N-Methyl-d-aspartate Receptor Function and Brain-derived Neurotrophic Factor Expression via RACK1*
We recently identified a novel mechanism for modulation of the phosphorylation state and function of theN-methyl-d-aspartate… 
Highly Cited
2002
Highly Cited
2002
Phylogenetic and expression analysis of the glutamate-receptor-like gene family in Arabidopsis thaliana.
The ionotropic glutamate receptor (iGluR) gene family has been widely studied in animals and is determined to be important in… 
Highly Cited
2001
Highly Cited
2001
Motoneuron-Specific Expression of NR3B, a Novel NMDA-Type Glutamate Receptor Subunit That Works in a Dominant-Negative Manner
We have identified a novel glutamate receptor subunit on the human and mouse genome. Cloning of the mouse cDNA revealed a protein… 
Highly Cited
1996
Highly Cited
1996
Enhanced tyrosine phosphorylation of the 2B subunit of the N-methyl-D-aspartate receptor in long-term potentiation.
Both serine/threonine and tyrosine phosphorylation of receptor proteins have been implicated in the process of long-term… 
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