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Afferent modulation of dopamine neuron firing differentially regulates tonic and phasic dopamine transmission
Dissociable regulation of dopamine neuron discharge by two separate afferent systems in rats is reported; inhibition of pallidal afferents selectively increased the population activity of dopamine neurons, whereas activation of pedunculopontine inputs increased burst firing. Expand
Regulation of firing of dopaminergic neurons and control of goal-directed behaviors
This work provides a systems-oriented approach to interpreting the function of the dopamine system, its modulation of limbic-cortical interactions and how disruptions within this system might underlie the pathophysiology of schizophrenia and drug abuse. Expand
Dopaminergic and Glutamatergic Regulation of Effort- and Delay-Based Decision Making
The utility of these procedures in pharmacologically dissociating the neurochemical mechanisms underlying these different, yet interrelated forms of decision making are highlighted and it is suggested that dopamine and NMDA receptors make dissociable contributions to these different types of cost–benefit analyses. Expand
Selective Roles for Hippocampal, Prefrontal Cortical, and Ventral Striatal Circuits in Radial-Arm Maze Tasks With or Without a Delay
Functional interactions between the hippocampus, the prefrontal cortex, and the ventral striatum in rats during the performance of delayed and nondelayed spatially cued radial-arm maze tasks suggest that different aspects of spatially mediated behavior are subserved by separate, distributed limbic–cortical–striatal networks. Expand
Glutamatergic Afferents from the Hippocampus to the Nucleus Accumbens Regulate Activity of Ventral Tegmental Area Dopamine Neurons
Data show that glutamatergic afferents from the vSub to the NAc exert a potent excitatory effect on VTA DA neurons, influencing both DA neuron population activity and the regulation of the firing properties of these neurons. Expand
Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes
The studies show that the HD gene is essential for postimplantation development and that it may play an important role in normal functioning of the basal ganglia. Expand
Orexin A/Hypocretin-1 Selectively Promotes Motivation for Positive Reinforcers
Evidence is shown that orexin/hypocretin receptor-1 (ox/hcrt-1R) signaling is important for motivation for highly salient, positive reinforcement and may represent a unique opportunity to design novel therapies that selectively reduce excessive drive to consume positive reinforcers of high salience. Expand
Inactivation of the medial prefrontal cortex of the rat impairs strategy set-shifting, but not reversal learning, using a novel, automated procedure
Findings highlight the utility of this automated procedure for assessing set-shifting mediated by the mPFC and reveal that the relative difficulty of the type of shift rats are required to perform has a direct impact on whether or not themPFC contributes to this form of behavioral flexibility. Expand
D1 Receptor Modulation of Hippocampal–Prefrontal Cortical Circuits Integrating Spatial Memory with Executive Functions in the Rat
The data suggest that D1receptors in the PFC are involved in working memory processes other than just the short-term active retention of information and also provide direct evidence for DA modulation of limbic–PFC circuits during behavior. Expand
The nucleus accumbens: an interface between cognition, emotion, and action.
  • S. Floresco
  • Psychology, Medicine
  • Annual review of psychology
  • 5 January 2015
Different subregions of the NAc play dissociable roles in refining action selection, promoting approach toward motivationally relevant stimuli, suppressing inappropriate actions so that goals may be obtained more efficiently, and encoding action outcomes that guide the direction of subsequent ones. Expand