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GRIN2B gene

Known as: glutamate ionotropic receptor NMDA type subunit 2B, N-METHYL-D-ASPARTATE RECEPTOR CHANNEL, SUBUNIT EPSILON-2, GluN2B 
This gene plays a role in both neurotransmitter binding and ion transport.
National Institutes of Health

Related topics

Related topics

7 relations
GRIN2B protein, humanHomo sapiensIonophore activityLigand Binding

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2019
Highly Cited
2019
l-Serine dietary supplementation is associated with clinical improvement of loss-of-function GRIN2B-related pediatric encephalopathy
Dietary l-serine supplements correct NMDAR deficiency and neurodevelopmental defects in a pediatric patient. Treating NMDA… 
Review
2017
Review
2017
Genetics of Alzheimer’s Disease: the Importance of Polygenic and Epistatic Components
Purpose of ReviewWe aimed to summarize the recent advances in genetic findings of Alzheimer’s disease (AD), focusing on… 
Highly Cited
2016
Highly Cited
2016
A Novel Binding Mode Reveals Two Distinct Classes of NMDA Receptor GluN2B-selective Antagonists
N-methyl-d-aspartate receptors (NMDARs) are glutamate-gated ion channels that play key roles in brain physiology and pathology… 
Highly Cited
2015
Highly Cited
2015
DRD and GRIN2B polymorphisms and their association with the development of impulse control behaviour among Malaysian Parkinson’s disease patients
BackgroundImpulse control disorder (ICD) and behaviours (ICB) represent a group of behavioural disorders that have become… 
Highly Cited
2014
Highly Cited
2014
Three rare diseases in one Sib pair: RAI1, PCK1, GRIN2B mutations associated with Smith-Magenis Syndrome, cytosolic PEPCK deficiency and NMDA receptor glutamate insensitivity.
Highly Cited
2013
Highly Cited
2013
Status epilepticus triggers early and late alterations in brain-derived neurotrophic factor and NMDA glutamate receptor Grin2b DNA methylation levels in the hippocampus
Highly Cited
2009
Highly Cited
2009
Structural Basis of NR2B-Selective Antagonist Recognition by N-Methyl-d-aspartate Receptors
N-Methyl-d-aspartate receptors (NMDARs) are ionotropic glutamate receptors endowed with unique pharmacological and functional… 
Highly Cited
2007
Highly Cited
2007
Association of the glutamate receptor subunit gene GRIN2B with attention‐deficit/hyperactivity disorder
The glutamatergic signaling pathway represents an ideal candidate susceptibility system for attention‐deficit/hyperactivity… 
Highly Cited
2005
Highly Cited
2005
An association study of the N-methyl-D-aspartate receptor NR1 subunit gene (GRIN1) and NR2B subunit gene (GRIN2B) in schizophrenia with universal DNA microarray
Dysfunction of the N-methyl-D-aspartate (NMDA) receptors has been implicated in the etiology of schizophrenia based on… 
Highly Cited
2001
Highly Cited
2001
Association analysis for NMDA receptor subunit 2B (GRIN2B) genetic variants and psychopathology and clozapine response in schizophrenia
It is known that a syndrome resembling schizophrenia is produced by the N-methyl-d-aspartate receptor antagonists. It has also… 
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