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Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters
Na+/Cl--dependent transporters terminate synaptic transmission by using electrochemical gradients to drive the uptake of neurotransmitters, including the biogenic amines, from the synapse to theExpand
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Principles of activation and permeation in an anion-selective Cys-loop receptor
Fast inhibitory neurotransmission is essential for nervous system function and is mediated by binding of inhibitory neurotransmitters to receptors of the Cys-loop family embedded in the membranes ofExpand
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Structure of acid-sensing ion channel 1 at 1.9 A resolution and low pH.
Acid-sensing ion channels (ASICs) are voltage-independent, proton-activated receptors that belong to the epithelial sodium channel/degenerin family of ion channels and are implicated in perception ofExpand
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X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor
Ionotropic glutamate receptors mediate most excitatory neurotransmission in the central nervous system and function by opening a transmembrane ion channel upon binding of glutamate. Despite theirExpand
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Crystal structure of the ATP-gated P2X4 ion channel in the closed state
P2X receptors are cation-selective ion channels gated by extracellular ATP, and are implicated in diverse physiological processes, from synaptic transmission to inflammation to the sensing of tasteExpand
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Structure of a glutamate transporter homologue from Pyrococcus horikoshii
Glutamate transporters are integral membrane proteins that catalyse the concentrative uptake of glutamate from the synapse to intracellular spaces by harnessing pre-existing ion gradients. In theExpand
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Molecular mechanism of ATP binding and ion channel activation in P2X receptors
P2X receptors are trimeric ATP-activated ion channels permeable to Na+, K+ and Ca2+. The seven P2X receptor subtypes are implicated in physiological processes that include modulation of synapticExpand
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Mechanism of glutamate receptor desensitization
Ligand-gated ion channels transduce chemical signals into electrical impulses by opening a transmembrane pore in response to binding one or more neurotransmitter molecules. After activation, manyExpand
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Mechanisms for Activation and Antagonism of an AMPA-Sensitive Glutamate Receptor Crystal Structures of the GluR2 Ligand Binding Core
Crystal structures of the GluR2 ligand binding core (S1S2) have been determined in the apo state and in the presence of the antagonist DNQX, the partial agonist kainate, and the full agonists AMPAExpand
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Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter
Secondary transporters are integral membrane proteins that catalyse the movement of substrate molecules across the lipid bilayer by coupling substrate transport to one or more ion gradients, therebyExpand
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