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GPR68 gene

Known as: OGR1, G protein-coupled receptor 68, G Protein-Coupled Receptor 68 Gene 
This gene is involved in G protein-coupled receptor signal transduction and pH homeostasis.
National Institutes of Health

Related topics

Related topics

7 relations
Acid-Base EquilibriumG Protein-Coupled Receptor SignalingGPR68 protein, humanLigand Binding

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GPR68 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
G protein-coupled pH-sensing receptor OGR1 and metabolic acidosis-induced hypercalciuria.
2019
2019
Abstract 1846: Acid sensing G protein-coupled receptor OGR1 is required for acid induced adiposomogenesis in breast cancer cells
Malignant tumors exhibit altered metabolism and consume higher levels of glucose compared to surrounding normal tissue, resulting… 
2019
2019
Abstract 118: GPR68, a proton-sensing GPCR that mediates interaction of pancreatic cancer associated fibroblasts and cancer cells, is a potential therapeutic target for pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a dense fibrotic stroma (desmoplasia) that is generated by pancreatic… 
2018
2018
82 - Activation of PH-Sensing Receptor OGR1 (GPR68) Induces ER Stress and Autophagy in an Intestinal Epithelial Cell Model
2018
2018
P087 A novel OGR1 (GPR68) inhibitor attenuates inflammation in a murine model of Acute Colitis
2016
2016
Heteromerization of G2A and OGR1 enhances proton sensitivity and proton-induced calcium signals
Abstract Proton-sensing G-protein-coupled receptors (GPCRs; OGR1, GPR4, G2A, TDAG8), with full activation at pH 6.4 ∼ 6.8, are… 
2016
2016
Promiscuous mechanisms underlie the antitumor effects of thalidomide analogs
Two recent studies provide novel insights into the mechanism of action of thalidomide analogs in multiple myeloma and del(5q… 
2006
2006
Sphingosylphosphorylcholine enhances calcium entry in thyroid FRO cells by a mechanism dependent on protein kinase C.
2006
2006
Reduced BMD in mice lacking the pH-sensing receptor TDAG8 but not OGR1.
2005
2005
Identification of T Cell Death-associated Gene 8 ( TDAG 8 ) as a Novel Acid Sensing G-protein-coupled Receptor *
T cell death-associated gene 8 (TDAG8) is a G-proteincoupled receptor mainly expressed in lymphoid organs and cancer tissues… 
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