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Why do cancers have high aerobic glycolysis?
If carcinogenesis occurs by somatic evolution, then common components of the cancer phenotype result from active selection and must, therefore, confer a significant growth advantage. A near-universalExpand
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Decoding tumour phenotype by noninvasive imaging using a quantitative radiomics approach
Human cancers exhibit strong phenotypic differences that can be visualized noninvasively by medical imaging. Radiomics refers to the comprehensive quantification of tumour phenotypes by applying aExpand
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Radiomics: Images Are More than Pictures, They Are Data
This report describes the process of radiomics, its challenges, and its potential power to facilitate better clinical decision making, particularly in the care of patients with cancer.
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Radiomics: extracting more information from medical images using advanced feature analysis.
Solid cancers are spatially and temporally heterogeneous. This limits the use of invasive biopsy based molecular assays but gives huge potential for medical imaging, which has the ability to captureExpand
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Radiomics: the process and the challenges.
"Radiomics" refers to the extraction and analysis of large amounts of advanced quantitative imaging features with high throughput from medical images obtained with computed tomography, positronExpand
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MRI of the tumor microenvironment.
The microenvironment within tumors is significantly different from that in normal tissues. A major difference is seen in the chaotic vasculature of tumors, which results in unbalanced blood supplyExpand
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Corrigendum: Decoding tumour phenotype by noninvasive imaging using a quantitative radiomics approach
Corrigendum: Decoding tumour phenotype by noninvasive imaging using a quantitative radiomics approach
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Causes and Consequences of Increased Glucose Metabolism of Cancers
In this review we examine the mechanisms (causes) underlying the increased glucose consumption observed in tumors within a teleological context (consequences). In other words, we will ask not onlyExpand
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A microenvironmental model of carcinogenesis
We propose that carcinogenesis requires tumour populations to surmount six distinct microenvironmental proliferation barriers that arise in the adaptive landscapes of normal and premalignantExpand
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Acidity generated by the tumor microenvironment drives local invasion.
The pH of solid tumors is acidic due to increased fermentative metabolism and poor perfusion. It has been hypothesized that acid pH promotes local invasive growth and metastasis. The hypothesis thatExpand
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