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GMP synthase (glutamine hydrolysing)

Known as: GMP Synthetase, GMP Synthase [Glutamine-Hydrolyzing], Glutamine Amidotransferase 
GMP synthase [glutamine-hydrolyzing] (693 aa, ~77 kDa) is encoded by the human GMPS gene. This protein plays a role in the biosynthesis of guanine… Expand
National Institutes of Health

Related topics

Related topics

9 relations
CytoplasmEnzyme GeneGMP synthase (glutamine-hydrolysing) activityGMPS gene
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Broader (2)

GMP synthaseLigase

Papers overview

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Highly Cited
2009
Highly Cited
2009
Glucosinolate engineering identifies a gamma-glutamyl peptidase.
Consumption of cruciferous vegetables is associated with reduced risk of developing cancer, a phenomenon attributed to… Expand
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Highly Cited
2006
Highly Cited
2006
Toward a Molecular Understanding of Pleiotropy
Pleiotropy refers to the observation of a single gene influencing multiple phenotypic traits. Although pleiotropy is a common… Expand
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Highly Cited
2006
Highly Cited
2006
Ammonia Channel Couples Glutaminase with Transamidase Reactions in GatCAB
The formation of glutaminyl transfer RNA (Gln-tRNAGln) differs among the three domains of life. Most bacteria employ an indirect… Expand
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Highly Cited
2003
Highly Cited
2003
The Crystal Structure of DJ-1, a Protein Related to Male Fertility and Parkinson's Disease*
DJ-1 is a multifunctional protein that plays essential roles in tissues with higher order biological functions such as the testis… Expand
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Review
2003
Review
2003
Enzymes with molecular tunnels.
As a result of recent advances in molecular cloning, protein expression, and X-ray crystallography, it has now become feasible to… Expand
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Highly Cited
1999
Highly Cited
1999
The crystal structure of anthranilate synthase from Sulfolobus solfataricus: functional implications.
Anthranilate synthase catalyzes the synthesis of anthranilate from chorismate and glutamine and is feedback-inhibited by… Expand
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Highly Cited
1997
Highly Cited
1997
Coupled formation of an amidotransferase interdomain ammonia channel and a phosphoribosyltransferase active site.
Activation of gluatmine phosphoribosylpyrophosphate (RPPP) amidotransferase (GPATase) by binding of a PRPP substrate analog… Expand
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Highly Cited
1996
Highly Cited
1996
The crystal structure of GMP synthetase reveals a novel catalytic triad and is a structural paradigm for two enzyme families
The crystal structure of GMP synthetase serves as a prototype for two families of metabolic enzymes. The Class I glutamine… Expand
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Highly Cited
1993
Highly Cited
1993
Synthesis of 2,4-disubstituted thiazoles and selenazoles as potential antifilarial and antitumor agents. 2. 2-Arylamido and 2-alkylamido derivatives of 2-amino-4-(isothiocyanatomethyl)thiazole and 2…
The synthesis of a series of 2-arylamido and 2-alkylamido derivatives of 2-amino-4-(isothiocyanatomethyl)thiazole and 2-amino-4… Expand
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Highly Cited
1991
Highly Cited
1991
Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance.
Based on our previous finding that desensitization of the insulin-responsive glucose transport system (GTS) requires three… Expand
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