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GJB2 protein, human

Known as: Connexin 26, Gap Junction Protein Beta 2, Connexin-26 
Gap junction beta-2 protein (226 aa, ~26 kDa) is encoded by the human GJB2 gene. This protein plays a role in gap junction-mediated facilitated… 
National Institutes of Health

Related topics

Related topics

14 relations
Cellular MembraneGJB2 geneGap JunctionsHearing

Broader (2)

ConnexinsGap Junction beta-2 protein

Papers overview

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Review
2011
Review
2011
Structure of the gap junction channel and its implications for its biological functions
Gap junctions consist of arrays of intercellular channels composed of integral membrane proteins called connexin in vertebrates… 
Highly Cited
2005
Highly Cited
2005
A novel deletion involving the connexin-30 gene, del(GJB6-d13s1854), found in trans with mutations in the GJB2 gene (connexin-26) in subjects with DFNB1 non-syndromic hearing impairment
Hearing impairment is a common and highly heterogeneous sensory disorder. Genetic causes are thought to be responsible for more… 
Highly Cited
2002
Highly Cited
2002
Connexin family members target to lipid raft domains and interact with caveolin-1.
Lipid rafts are cholesterol-sphingolipid-rich microdomains that function as platforms for membrane trafficking and signal… 
Highly Cited
2002
Highly Cited
2002
Retroviral Delivery of Connexin Genes to Human Breast Tumor Cells Inhibits in Vivo Tumor Growth by a Mechanism That Is Independent of Significant Gap Junctional Intercellular Communication*
The mechanism by which gap junction proteins, connexins, act as potent tumor suppressors remains poorly understood. In this study… 
Highly Cited
2001
Highly Cited
2001
Connexin26 in adult rodent central nervous system: Demonstration at astrocytic gap junctions and colocalization with connexin30 and connexin43
The connexin family of proteins (Cx) that form intercellular gap junctions in vertebrates is well represented in the mammalian… 
Highly Cited
2001
Highly Cited
2001
Multiple pathways in the trafficking and assembly of connexin 26, 32 and 43 into gap junction intercellular communication channels.
The assembly of gap junctions was investigated in mammalian cells expressing connexin (Cx) 26, 32 and 43 fused to green, yellow… 
Highly Cited
2000
Highly Cited
2000
A role for heterologous gap junctions between melanoma and endothelial cells in metastasis.
F10 and BL6 sublines of B16 mouse melanoma cells are metastatic after intravenous injection, but only BL6 cells are metastatic… 
Highly Cited
1996
Highly Cited
1996
Gap junction genes Cx26 and Cx43 individually suppress the cancer phenotype of human mammary carcinoma cells and restore differentiation potential.
Normal human mammary epithelial cells express hcx43 and hCx26 proteins, which form functional gap junction channels. Both Cx… 
Highly Cited
1995
Highly Cited
1995
The Gap Junction Proteins β1-Connexin (Connexin-32) and β2-Connexin (Connexin-26) Can Form Heteromeric Hemichannels
Highly Cited
1992
Highly Cited
1992
Four novel members of the connexin family of gap junction proteins. Molecular cloning, expression, and chromosome mapping.
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