• Publications
  • Influence
Caveolae: From Cell Biology to Animal Physiology
TLDR
The purpose of this review is to explicate what is known about caveolins/caveolae and highlight growing areas of caveolar research.
Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities.
TLDR
The results indicate that eNOS activity is up-regulated in Cav-1 null animals, and this activity can be blunted by using a specific NOS inhibitor, nitro-l-arginine methyl ester.
Caveolins, a Family of Scaffolding Proteins for Organizing “Preassembled Signaling Complexes” at the Plasma Membrane*
TLDR
Because the responsibilities assigned to caveolae continue to increase, this review will focus on: (i) caveolin structure/function and (ii) Caveolae-associated signal transduction.
Identification of Peptide and Protein Ligands for the Caveolin-scaffolding Domain
TLDR
The Caveolin-scaffolding domain is used as a receptor to select random peptide ligands from phage display libraries and it is found that the scaffolding domains of caveolins 1 and 3 both recognize the same peptide and protein ligands, whereas the corresponding domain within caveolin-2 fails to recognize these ligands under the same conditions.
Caveolins, Liquid-Ordered Domains, and Signal Transduction
TLDR
This review seeks to update the working definition of caveolae, describe the functional roles of the caveolin gene family, and summarize the evidence that supports a role for Caveolae as mediators of a number of cellular signaling processes.
Role of caveolae and caveolins in health and disease.
TLDR
The mechanisms by which caveolae and caveolins participate in human disease processes are provided, including diabetes, cancer, cardiovascular disease, atherosclerosis, pulmonary fibrosis, and a variety of degenerative muscular dystrophies.
Co-purification and Direct Interaction of Ras with Caveolin, an Integral Membrane Protein of Caveolae Microdomains
TLDR
It is shown that caveolin interacts with another well characterized signal transducer, Ras, and that recombinant overexpression of caveolin in intact cells is sufficient to functionally recruit a nonfarnesylated mutant of Ras onto membranes, overcoming the normal requirement for lipid modification of Ras.
Characterization of caveolin-rich membrane domains isolated from an endothelial-rich source: implications for human disease
TLDR
Characterization of these complexes by micro-sequencing and immuno- blotting reveals known receptors for modified forms of LDL, multiple GPI-linked proteins, an anion transporter, cytoskeletal elements, and cytoplasmic signaling molecules--including Src-like kinases, hetero- trimeric G-proteins, and three members of the Rap family of small GTPases.
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
TLDR
There continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes, so it is important to update guidelines for monitoring autophagic activity in different organisms.
Signal transducing molecules and glycosyl-phosphatidylinositol-linked proteins form a caveolin-rich insoluble complex in MDCK cells
TLDR
It is proposed that caveolin could function as a transmembrane adaptor molecule that couples luminal G PI-linked proteins with cytoplasmically oriented signaling molecules during GPI- Membrane trafficking or GPI -mediated signal transduction events.
...
1
2
3
4
5
...