• Publications
  • Influence
Life cycle of connexins in health and disease.
  • D. Laird
  • Medicine, Biology
  • The Biochemical journal
  • 15 March 2006
Evaluation of the human genome suggests that all members of the connexin family of gap-junction proteins have now been successfully identified. This large and diverse family of proteins facilitates aExpand
  • 682
  • 69
Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis
Apoptotic cells release ‘find-me’ signals at the earliest stages of death to recruit phagocytes. The nucleotides ATP and UTP represent one class of find-me signals, but their mechanism of release isExpand
  • 706
  • 49
Pannexin 1 and pannexin 3 are glycoproteins that exhibit many distinct characteristics from the connexin family of gap junction proteins
Pannexins are mammalian orthologs of the invertebrate gap junction proteins innexins and thus have been proposed to play a role in gap junctional intercellular communication. Localization ofExpand
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Multicolor and Electron Microscopic Imaging of Connexin Trafficking
Recombinant proteins containing tetracysteine tags can be successively labeled in living cells with different colors of biarsenical fluorophores so that older and younger protein molecules can beExpand
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Turnover and phosphorylation dynamics of connexin43 gap junction protein in cultured cardiac myocytes.
Cultured cardiomyocytes were used to study the turnover and post-translational modification of connexin43 (Cx43), a major gap junction protein in neonatal cardiac myocytes. Immunoprecipitation ofExpand
  • 412
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The gap junction proteome and its relationship to disease.
  • D. Laird
  • Medicine, Biology
  • Trends in cell biology
  • 1 February 2010
In recent years our understanding of connexins has advanced from viewing them simply as proteins with a surprisingly short lifespan that form gap junction channels. Connexins are now known to beExpand
  • 243
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Sex-specific exons control DNA methyltransferase in mammalian germ cells.
The spermatozoon and oocyte genomes bear sex-specific methylation patterns that are established during gametogenesis and are required for the allele-specific expression of imprinted genes in somaticExpand
  • 343
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The biochemistry and function of pannexin channels.
Three family members compose the pannexin family of channel-forming glycoproteins (Panx1, Panx2 and Panx3). Their primary function is defined by their capacity to form single-membrane channels thatExpand
  • 241
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Genetic correlates of in vivo viral resistance to indinavir, a human immunodeficiency virus type 1 protease inhibitor.
Indinavir (IDV) (also called CRIXIVAN, MK-639, or L-735,524) is a potent and selective inhibitor of the human immunodeficiency virus type 1 (HIV-1) protease. During early clinical trials, in whichExpand
  • 409
  • 19
Glycosylation regulates pannexin intermixing and cellular localization.
The pannexin family of mammalian proteins, composed of Panx1, Panx2, and Panx3, has been postulated to be a new class of single-membrane channels with functional similarities to connexin gap junctionExpand
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