• Publications
  • Influence
Structure of the connexin 26 gap junction channel at 3.5 Å resolution
TLDR
The crystal structure of the gap junction channel formed by human connexin 26 (Cx26), also known as GJB2, is reported at 3.5 Å resolution, and structural determinants of solute transport through the channel are discussed.
The Whole Structure of the 13-Subunit Oxidized Cytochrome c Oxidase at 2.8 Å
TLDR
Two possible proton pathways for pumping, each spanning from the matrix to the cytosolic surfaces, were identified, including hydrogen bonds, internal cavities likely to contain water molecules, and structures that could form hydrogen bonds with small possible conformational change of amino acid side chains.
The low-spin heme of cytochrome c oxidase as the driving element of the proton-pumping process
TLDR
It is reported that the Asp-51 → Asn mutation of the bovine enzyme abolishes its proton-pumping function without impairment of the dioxygen reduction activity.
Redox-coupled crystal structural changes in bovine heart cytochrome c oxidase.
TLDR
Crystal structures of bovine heart cytochrome c oxidase in the fully oxidized, fully reduced, azide-bound, and carbon monoxide-bound states were determined at 2.35, 2.9, and 2.8 angstrom resolution, indicating the aspartate as the as partate pumping site for the O2 reduction by the enzyme.
Structures of metal sites of oxidized bovine heart cytochrome c oxidase at 2.8 A
TLDR
The high resolution three-dimensional x-ray structure of the metal sites of bovine heart cytochrome c oxidase is reported, suggesting a dinuclear copper center with an unexpected structure similar to a [2Fe-2S]-type iron-sulfur center.
Crystal Structure of the Membrane Fusion Protein, MexA, of the Multidrug Transporter in Pseudomonas aeruginosa*
TLDR
The MexAB-OprM efflux pump of Pseudomonas aeruginosa is central to multidrug resistance of this organism and the MexA subunit connected MexB and OprM, indicating that MexA is the membrane bridge protein.
Crystal Structure of the Drug Discharge Outer Membrane Protein, OprM, of Pseudomonas aeruginosa
TLDR
The OprM lipoprotein of Pseudomonas aeruginosa is a member of the MexAB-OprM xenobiotic-antibiotic transporter subunits that is assumed to serve as the drug discharge duct across the outer membrane and the crystal structure offers possible mechanisms of pore opening and pump assembly.
Structures and physiological roles of 13 integral lipids of bovine heart cytochrome c oxidase
TLDR
The phosphatidylglycerol with vaccenate was found in CcOs of bovine and Paracoccus denitrificans, the ancestor of mitochondrion, indicating that thevaccenate is conserved in Bovine CcO in spite of the abundance of oleate.
Crystal structure of N-carbamyl-D-amino acid amidohydrolase with a novel catalytic framework common to amidohydrolases.
TLDR
DCase shows only weak sequence similarity with a family of amidohydrolases, including beta-alanine synthase, aliphatic amidases and nitrilases, but might share highly conserved residues in a novel framework, which could provide a possible explanation for the catalytic mechanism for this family of enzymes.
Structure of human monoamine oxidase A at 2.2-Å resolution: The control of opening the entry for substrates/inhibitors
TLDR
The results suggest that the flexibility of loop 108–118, facilitated by anchoring the enzyme into the membrane, is essential for controlling substrate access to the active site.
...
1
2
3
4
5
...