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GJA8 gene

Known as: GAP JUNCTION PROTEIN, ALPHA-8, CX50, GJA8 
National Institutes of Health

Related topics

Related topics

3 relations
CATARACT, NUCLEAR PROGRESSIVEGJC1 geneconnexin 50

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
Aquaporin 0 enhances gap junction coupling via its cell adhesion function and interaction with connexin 50
Both connexin 50 (Cx50) and aquaporin 0 (AQP0) have important roles in lens development and homeostasis, and their mutations are… 
Highly Cited
2007
Highly Cited
2007
Genetic heterogeneity in microcornea-cataract: five novel mutations in CRYAA, CRYGD, and GJA8.
PURPOSE To unravel the molecular genetic background in families with congenital cataract in association with microcornea (CCMC… 
Highly Cited
2004
Highly Cited
2004
Potent block of Cx36 and Cx50 gap junction channels by mefloquine.
Recently, great interest has been shown in understanding the functional roles of specific gap junction proteins (connexins) in… 
Highly Cited
2004
Highly Cited
2004
Connexins are mechanosensitive.
Connexins form gap junction channels that provide a hydrophilic path between cell interiors. Some connexins, particularly the… 
Highly Cited
2002
Highly Cited
2002
Connexin family members target to lipid raft domains and interact with caveolin-1.
Lipid rafts are cholesterol-sphingolipid-rich microdomains that function as platforms for membrane trafficking and signal… 
Highly Cited
2000
Highly Cited
2000
Electrical properties of gap junction hemichannels identified in transfected HeLa cells
Abstract. Human HeLa cells transfected with mouse connexin Cx30, Cx46 or Cx50 were used to study the electrical properties of gap… 
Review
2000
Review
2000
Connexin gene mutations in human genetic diseases.
Highly Cited
1999
Highly Cited
1999
Hetero-domain interactions as a mechanism for the regulation of connexin channels.
Previous studies have shown that chemical regulation of connexin43 (Cx43) depends on the presence of the carboxyl terminal (CT… 
Highly Cited
1995
Highly Cited
1995
Functional analysis of selective interactions among rodent connexins.
One consequence of the diversity in gap junction structural proteins is that cells expressing different connexins may come into… 
Highly Cited
1994
Highly Cited
1994
Selective interactions among the multiple connexin proteins expressed in the vertebrate lens: the second extracellular domain is a determinant of compatibility between connexins
Gap junctions are collections of intercellular channels composed of structural proteins called connexins (Cx). We have examined… 
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