F. Sachs

Publications274
h-index65
Citations14,824
Highly Influential Citations612
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Estimating single-channel kinetic parameters from idealized patch-clamp data containing missed events.
Energetic and Spatial Parameters for Gating of the Bacterial Large Conductance Mechanosensitive Channel, MscL
TLDR
The tension dependence of channel gating is primarily one of increasing the external channel area to accommodate the pore of the smallest conducting state and the in-plane area change from closed to fully open was 6 nm2, agreeing with the value obtained in the two-state analysis.
Block of stretch-activated ion channels in Xenopus oocytes by gadolinium and calcium ions.
TLDR
The availability of a blocker for SA ion channels may help to define their physiological function, and will simplify the use of oocytes as an expression system for ion channels.
Identification of a Peptide Toxin from Grammostola spatulata Spider Venom That Blocks Cation-Selective Stretch-Activated Channels
TLDR
A 35 amino acid peptide toxin of the inhibitor cysteine knot family that blocks cationic stretch-activated ion channels is identified and implicates SACs in volume regulation.
Stretch‐activated single ion channel currents in tissue‐cultured embryonic chick skeletal muscle.
TLDR
The membrane of tissue‐cultured chick pectoral muscle contains an ionic channel which is activated by membrane stretch, and appears to gather force from a large area of membrane, probably by a cytochalasin‐resistant cytoskeletal network.
The mechanosensitive ion channel Piezo1 is inhibited by the peptide GsMTx4.
TLDR
The ability of GsMTx4 to target the mechanosensitivity of Piezo1 supports the use of this channel in high-throughput screens for pharmacological agents and diagnostic assays.
Single Channel Properties of P2X2 Purinoceptors
TLDR
The single channel properties of cloned P2X2 purinoceptors expressed in human embryonic kidney 293 cells and Xenopus oocytes were studied in outside-out patches and a model with four sequential closed states branching to two open states that converged on a final closed state was produced.
Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension
TLDR
It is shown PIEZO1 is activated by bilayer tension in bleb membranes, gating at lower pressures indicative of removal of the cortical cytoskeleton and the mechanoprotection it provides.
Effects of stretch‐activated channel blockers on [Ca2+]i and muscle damage in the mdx mouse
The mdx mouse lacks dystrophin and is a model of human Duchenne muscular dystrophy. Single mdx muscle fibres were isolated and subjected to a series of stretched (eccentric) contractions while…
Mechanosensitive ion channels and the peptide inhibitor GsMTx-4: history, properties, mechanisms and pharmacology.
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