• Publications
  • Influence
Two networks of electrically coupled inhibitory neurons in neocortex
Two functionally distinct inhibitory networks comprising either fast-spiking (FS) or low-threshold spiking (LTS) neurons are described, which may allow each inhibitory network to function independently. Expand
Comparative electrophysiology of pyramidal and sparsely spiny stellate neurons of the neocortex.
Slices of sensorimotor and anterior cingulate cortex from guinea pigs were maintained in vitro and bathed in a normal physiological medium, observing three distinct neuronal classes of electrophysiological behavior; these were regular spiking, bursting, and fast spiking. Expand
Two dynamically distinct inhibitory networks in layer 4 of the neocortex.
There are two parallel but dynamically distinct systems of synaptic inhibition in layer 4 of neocortex, each defined by its intrinsic spiking properties, the short-term plasticity of its chemical synapses, and an exclusive set of electrical synapses. Expand
Neuroscience: Exploring the Brain
Acclaimed for its clear, friendly style, excellent illustrations, leading author team, and compelling theme of exploration, Neuroscience: Exploring the Brain, 4e takes a fresh, contemporary approachExpand
Intrinsic firing patterns of diverse neocortical neurons
The different firing properties of neurons in neocortex contribute significantly to its network behavior, particularly in response to current steps. Expand
Synaptic basis for intense thalamocortical activation of feedforward inhibitory cells in neocortex
The thalamus provides fundamental input to the neocortex and activates inhibitory interneurons more strongly than excitatory neurons, triggering powerful feedforward inhibition and demonstrating the importance of selective synaptic targeting and precise timing in the initial stages of neocortical processing. Expand
Differential Regulation of Neocortical Synapses by Neuromodulators and Activity
The results suggest a mechanism by which the relative strength and dynamics of input and associational pathways of neocortex are regulated during changes in behavioral state. Expand
Thalamocortical responses of mouse somatosensory (barrel) cortexin vitro
The thalamo-cortical slice is a very suitable system for studying the physiology and pharmacology of the thalamocortical synapse and for exploring the synaptic circuitry of the somatosensory cortex. Expand
Electrophysiological properties of neocortical neurons in vitro.
The array of passive and active membrane behavior observed in the slice suggests that cortical neurons may be differentiated by specific functional properties as well as by their extensive morphological diversity. Expand
Potent block of Cx36 and Cx50 gap junction channels by mefloquine.
It is shown that mefloquine, an antimalarial drug, is one such agent that block specific connexins, without major effects on other gap junctions or membrane channels, and expected to be a useful tool to study the functional roles of Cx36 and Cx50. Expand