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GGTI 298

Known as: GGTI-298 
National Institutes of Health

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Related topics

1 relation

Broader (1)

Benzamides

Papers overview

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Highly Cited
2017
Highly Cited
2017
Cross-talk between autophagy and KLF2 determines endothelial cell phenotype and microvascular function in acute liver injury.
2007
2007
Adrenaline increases glucose transport via a Rap1‐p38MAPK pathway in rat vascular smooth muscle cells
Adrenaline has been implicated in the pathogenesis of atherosclerosis. However, little is known regarding the role of adrenaline… 
Highly Cited
2005
Highly Cited
2005
Statins Exert Endothelial Atheroprotective Effects via the KLF2 Transcription Factor*
3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, statins, have been shown to positively impact vascular function… 
Highly Cited
2002
Highly Cited
2002
Statin enhances cytokine-mediated induction of nitric oxide synthesis in vascular smooth muscle cells.
Highly Cited
2001
Highly Cited
2001
Nitrogen-bisphosphonates block retinoblastoma phosphorylation and cell growth by inhibiting the cholesterol biosynthetic pathway in a keratinocyte model for esophageal irritation.
The surprising discovery that nitrogen-containing bisphosphonates (N-BPs) act via inhibition of the mevalonate-to-cholesterol… 
Highly Cited
2000
Highly Cited
2000
Protein Geranylgeranylation Is Required for Osteoclast Formation, Function, and Survival: Inhibition by Bisphosphonates and GGTI‐298
Bisphosphonates are the important class of antiresorptive drugs used in the treatment of metabolic bone diseases. Although their… 
Highly Cited
1998
Highly Cited
1998
p21WAF1/CIP1 Is Upregulated by the Geranylgeranyltransferase I Inhibitor GGTI-298 through a Transforming Growth Factor β- and Sp1-Responsive Element: Involvement of the Small GTPase RhoA
ABSTRACT We have recently reported that the geranylgeranyltransferase I inhibitor GGTI-298 arrests human tumor cells at the… 
Highly Cited
1997
Highly Cited
1997
GGTI-298 induces G0-G1 block and apoptosis whereas FTI-277 causes G2-M enrichment in A549 cells.
The mechanism by which the geranylgeranyltransferase I inhibitor GGTI-298 and the farnesyltransferase inhibitor FTI-277 inhibit… 
Highly Cited
1996
Highly Cited
1996
Protein geranylgeranylation, not farnesylation, is required for the G1 to S phase transition in mouse fibroblasts.
In order to assess the relative contributions of farnesylated and/or geranylgeranylated proteins on cell cycle progression from… 
Highly Cited
1996
Highly Cited
1996
Platelet-derived Growth Factor Receptor Tyrosine Phosphorylation Requires Protein Geranylgeranylation but not Farnesylation*
We have used specific inhibitors for farnesyltransferase (FTase) and geranylgeranyltransferase (GGTase) I as well as combinations… 
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