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GGTI 298

Known as: GGTI-298 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Benzamides

Papers overview

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2016
2016
Effect of HMG-CoA Reductase Inhibition on Vascular Smooth Muscle Cells Extracellular Matrix Production: Role of RhoA.
Cholesterol-lowering effects apart, statins can improve the endothelial function, stabilize the atherosclerotic plaques, decrease… 
2015
2015
Endothelial protective genes induced by statin are mimicked by ERK5 activation as triggered by a drug combination of FTI-277 and GGTI-298.
2011
2011
Geranylgeranyl-pyrophosphate regulates secretion of pentraxin 3 and monocyte chemoattractant protein-1 from rheumatoid fibroblast-like synoviocytes in distinct manners.
OBJECTIVES We previously reported that 10 mg/day of simvastatin significantly reduced clinical scores of rheumatoid arthritis (RA… 
2006
2006
RhoA and Rac1 contribute to type III group B streptococcal invasion of human brain microvascular endothelial cells.
2006
2006
Atorvastatin desensitizes beta-adrenergic signaling in cardiac myocytes via reduced isoprenylation of G-protein gamma-subunits.
Statins exert pleiotropic, cholesterol-independent effects by reducing isoprenylation of monomeric GTPases. Here we examined… 
2005
2005
Geranylgeranyl transferase inhibition stimulates antimelanoma immune response through MHC class I and costimulatory molecule expression
Defective antitumor immune responses are frequent consequences of defects in the expression of major histocompatibility complex… 
Highly Cited
2002
Highly Cited
2002
Statin enhances cytokine-mediated induction of nitric oxide synthesis in vascular smooth muscle cells.
Highly Cited
1999
Highly Cited
1999
Integrin-dependent Leukocyte Adhesion Involves Geranylgeranylated Protein(s)*
Integrin-dependent leukocyte adhesion is modulated by alterations in receptor affinity or by post-receptor events. Pretreatment… 
1998
1998
Selective inhibition of type-I geranylgeranyltransferase in vitro and in whole cells by CAAL peptidomimetics.
1998
1998
Inhibiting geranylgeranylation blocks growth and promotes apoptosis in pulmonary vascular smooth muscle cells.
The activity of small GTP-binding proteins is regulated by a critical step in posttranslational processing, namely, the addition… 
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