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GCK gene

Known as: HEXOKINASE 4, GLUCOKINASE, HK4 
National Institutes of Health

Related topics

Related topics

4 relations
GALK2 geneGlucokinaseMAP4K1 genegerminal center kinases

Papers overview

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Highly Cited
2007
Highly Cited
2007
AICAR potentiates ROS production induced by chronic high glucose: roles of AMPK in pancreatic beta-cell apoptosis.
Highly Cited
2003
Highly Cited
2003
Isoform-specific insulin receptor signaling involves different plasma membrane domains
In pancreatic β-cells, insulin selectively up-regulates the transcription of its own gene and that of the glucokinase gene by… 
Highly Cited
2002
Highly Cited
2002
Foxa2 (HNF3β) Controls Multiple Genes Implicated in Metabolism-Secretion Coupling of Glucose-induced Insulin Release*
The transcription factor Foxa2 is implicated in blood glucose homeostasis. Conditional expression of Foxa2 or its dominant… 
Highly Cited
1997
Highly Cited
1997
Expression of Human Hepatic Glucokinase in Transgenic Mice Liver Results in Decreased Glucose Levels and Reduced Body Weight
Glucokinase is the predominant hexokinase in pancreatic β-cells and liver parenchymal cells and functions as a critical component… 
Highly Cited
1996
Highly Cited
1996
Differential Effects of Overexpressed Glucokinase and Hexokinase I in Isolated Islets
Glucose-stimulated insulin secretion is believed to require metabolism of the sugar via a high Kpathway in which glucokinase… 
Highly Cited
1995
Highly Cited
1995
In vivo effects of hyperinsulinemia on lipogenic enzymes and glucose transporter expression in rat liver and adipose tissues.
Review
1992
Review
1992
Glucokinase and NIDDM: A Candidate Gene That Paid Off
Glucokinase, the major enzyme that phosphorylates glucose upon entry into liver and islet β-cells, has been considered a prime… 
Highly Cited
1990
Highly Cited
1990
The mechanism by which rat liver glucokinase is inhibited by the regulatory protein.
The fructose-6-phosphate-sensitive and fructose-1-phosphate-sensitive protein that inhibits rat liver glucokinase [Van… 
Highly Cited
1976
Highly Cited
1976
Kinetics of rat liver glucokinase. Co-operative interactions with glucose at physiologically significant concentrations.
The kinetics of glucokinase from rat liver were studied over wide ranges of glucose and MgATP2- concentrations. The initial rate… 
Highly Cited
1959
Highly Cited
1959
Blood glucose and the liver.
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