Kinetics of rat liver glucokinase. Co-operative interactions with glucose at physiologically significant concentrations.

@article{Storer1976KineticsOR,
  title={Kinetics of rat liver glucokinase. Co-operative interactions with glucose at physiologically significant concentrations.},
  author={A. C. Storer and A. Cornish-Bowden},
  journal={The Biochemical journal},
  year={1976},
  volume={159 1},
  pages={7-14}
}
The kinetics of glucokinase from rat liver were studied over wide ranges of glucose and MgATP2- concentrations. The initial rate shows a co-operative dependence on the glucose concentration, with Hill coefficients in the range 1.2-1.5. The degree of glucose co-operativity increases with the MgATP2- concentration, but no co-operativity was detected for the dependence of the rate on the MgATP2- concentration. The effects observed occur at physiologically reasonable concentrations of glucose and… CONTINUE READING

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Regulation in Metabolism

  • E. A. Newsholme, C. Start
  • 1973

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