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Glucokinase

Known as: ATP:D-glucose 6-phosphotransferase, Glucokinase [Chemical/Ingredient] 
A group of enzymes that catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate. They are found in invertebrates and… 
National Institutes of Health

Related topics

Related topics

10 relations
GCK geneHEXOKINASEIn BloodProcess of secretion

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
Enantioselective Pd-catalyzed alpha-arylation of N-Boc-pyrrolidine: the key to an efficient and practical synthesis of a glucokinase activator.
A short and practical synthesis of glucokinase activator 1 was achieved utilizing a convergent strategy involving S(N)Ar coupling… 
2004
2004
Kinetic characteristics and regulatory mechanisms of glucokinase and fructokinase from Zymomonas mobilis
SummaryGlucokinase (EC 2.7.1.2) exhibits two pH optima (pH 7.0 and 8.2), gives hyperbolic saturation curves and reacts equally… 
Highly Cited
2002
Highly Cited
2002
ADP-dependent Glucokinase/Phosphofructokinase, a Novel Bifunctional Enzyme from the Hyperthermophilic ArchaeonMethanococcus jannaschii *
A gene encoding an ADP-dependent phosphofructokinase homologue has been identified in the hyperthermophilic archaeon… 
2000
2000
Investigation of the mechanism by which glucose analogues cause translocation of glucokinase in hepatocytes: evidence for two glucose binding sites.
Glucokinase translocates between the cytoplasm and nucleus of hepatocytes where it is bound to a 68 kDa protein. The mechanism by… 
Highly Cited
1996
Highly Cited
1996
Differential Effects of Overexpressed Glucokinase and Hexokinase I in Isolated Islets
Glucose-stimulated insulin secretion is believed to require metabolism of the sugar via a high Kpathway in which glucokinase… 
Highly Cited
1996
Highly Cited
1996
Amino Acid Conservation in Animal Glucokinases
To delineate the regions of liver glucokinase that are involved in the binding of its regulatory protein and have therefore been… 
Highly Cited
1995
Highly Cited
1995
The regulatory protein of glucokinase binds to the hepatocyte matrix, but, unlike glucokinase, does not translocate during substrate stimulation.
The kinetic properties of hepatic glucokinase (hexokinase IV) are modulated by binding to a regulatory protein. This study shows… 
Highly Cited
1990
Highly Cited
1990
Regulation of glucokinase by a fructose-1-phosphate-sensitive protein in pancreatic islets.
In the post-microsomal supernatant of pancreatic islets, prepared from fasted or fed rats, D-fructose 1-phosphate increased the… 
Highly Cited
1984
Highly Cited
1984
Suppression of kinetic cooperativity of hexokinase D (glucokinase) by competitive inhibitors. A slow transition model.
Hexokinase D ('glucokinase') displays positive cooperativity with mannose with the same h values (1.5-1.6) as with glucose but… 
Highly Cited
1983
Highly Cited
1983
Chromatographic resolution and kinetic characterization of glucokinase from islets of Langerhans.
Glucokinase (ATP:D-glucose 6-phosphotransferase, EC 2.7.1.2) from rat islets of Langerhans was partially purified by… 
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