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GART wt Allele

Known as: PGFT, GARFT, AIRS 
Human GART wild-type allele is located in the vicinity of 21q22.11 and is approximately 40 kb in length. This allele, which encodes trifunctional… 
National Institutes of Health

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6 relations
21q22.11AnabolismGART geneNucleotide Biosynthesis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2005
2005
Loss of reduced folate carrier function and folate depletion result in enhanced pemetrexed inhibition of purine synthesis.
Pemetrexed is a novel antifolate with polyglutamate derivatives that are potent inhibitors of thymidylate synthase (TS) and to a… 
Highly Cited
2004
Highly Cited
2004
AG2034: a novel inhibitor of glycinamide ribonucleotide formyltransferase
SummaryThe glycinamide ribonucleotide formyltransferase (GARFT) inhibitor, 4-[2-(2-amino-4-oxo-4,6,7,8-tetrahydro-3H-pyrimidino[5… 
2004
2004
A Phase I clinical study of the antipurine antifolate lometrexol (DDATHF) given with oral folic acid
SummaryLometrexol is an antifolate which inhibits glycinamide ribonucleotide formyltransferase (GARFT), an enzyme essential for… 
2004
2004
Biochemistry and pharmacology of glycinamide ribonucleotide formyltransferase inhibitors: LY309887 and lometrexol
SummaryLometrexol, a tight-binding antifolate inhibitor of the purine de novo enzyme glycinamide ribonucleotide formyltransferase… 
2001
2001
Efectividad de los programas de mantenimiento con metadona. Una revisión de los resultados de los estudios de evaluación
Review
1999
Review
1999
Preclinical and Clinical Evaluation of the Glycinamide Ribonucleotide Formyltransferase Inhibitors Lometrexol and LY309887
The importance of the purine de novo pathway in providing DNA precursors for cancer cell growth led to the hypothesis that novel… 
1997
1997
An inhibitor of glycinamide ribonucleotide formyltransferase is selectively cytotoxic to cells that lack a functional G1 checkpoint
Purpose: We studied the effects of purine depletion on the cell cycle using a specific inhibitor of de novo purine biosynthesis… 
1997
1997
Tight binding of folate substrates and inhibitors to recombinant mouse glycinamide ribonucleotide formyltransferase.
The binding of the prototypical folate inhibitor of de novo purine synthesis, 5,10-dideazatetrahydrofolate (DDATHF), and its… 
1997
1997
Un sistema de clasificación de pacientes para nuestra atención primaria: los ambulatory care groups (ACGs)
1992
1992
Biochemical and biological studies on 2-desamino-2-methylaminopterin, an antifolate the polyglutamates of which are more potent than the monoglutamate against three key enzymes of folate metabolism.
Biochemical and biological studies have been carried out with 2-desamino-2-methylaminopterin (dmAMT), which inhibits tumor cell… 
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