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GART wt Allele

Known as: PGFT, GARFT, AIRS 
Human GART wild-type allele is located in the vicinity of 21q22.11 and is approximately 40 kb in length. This allele, which encodes trifunctional… 
National Institutes of Health

Related topics

Related topics

6 relations
21q22.11AnabolismGART geneNucleotide Biosynthesis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Blending Study of Palm Oil Methyl Esters with Rubber Seed Oil Methyl Esters to Improve Biodiesel Blending Properties
Palm oil methyl esters (POME’s) significantly contributed towards biodiesel production commercially. Rubber seed oil methyl… 
2006
2006
Efficient chemoenzymatic synthesis of pelitrexol via enzymic differentiation of a remote stereocenter.
[structure: see text] An efficient chemoenzymatic process is described for the synthesis of pelitrexol, a novel GARFT inhibitor… 
Highly Cited
2004
Highly Cited
2004
AG2034: a novel inhibitor of glycinamide ribonucleotide formyltransferase
SummaryThe glycinamide ribonucleotide formyltransferase (GARFT) inhibitor, 4-[2-(2-amino-4-oxo-4,6,7,8-tetrahydro-3H-pyrimidino[5… 
2004
2004
A Phase I clinical study of the antipurine antifolate lometrexol (DDATHF) given with oral folic acid
SummaryLometrexol is an antifolate which inhibits glycinamide ribonucleotide formyltransferase (GARFT), an enzyme essential for… 
2004
2004
Biochemistry and pharmacology of glycinamide ribonucleotide formyltransferase inhibitors: LY309887 and lometrexol
SummaryLometrexol, a tight-binding antifolate inhibitor of the purine de novo enzyme glycinamide ribonucleotide formyltransferase… 
2004
2004
Inmigración y salud
Review
1999
Review
1999
Preclinical and Clinical Evaluation of the Glycinamide Ribonucleotide Formyltransferase Inhibitors Lometrexol and LY309887
The importance of the purine de novo pathway in providing DNA precursors for cancer cell growth led to the hypothesis that novel… 
1997
1997
An inhibitor of glycinamide ribonucleotide formyltransferase is selectively cytotoxic to cells that lack a functional G1 checkpoint
Purpose: We studied the effects of purine depletion on the cell cycle using a specific inhibitor of de novo purine biosynthesis… 
1997
1997
Tight binding of folate substrates and inhibitors to recombinant mouse glycinamide ribonucleotide formyltransferase.
The binding of the prototypical folate inhibitor of de novo purine synthesis, 5,10-dideazatetrahydrofolate (DDATHF), and its… 
Highly Cited
1973
Highly Cited
1973
On the organization and mechanism of prostaglandin synthetase.
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