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Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes
These findings indicate a function for pseudogenes in regulating gene expression by means of the RNA interference pathway and may, in part, explain the evolutionary pressure to conserve argonaute-mediated catalysis in mammals. Expand
Preimplantation development of mouse embryos in KSOM: Augmentation by amino acids and analysis of gene expression
- Y. Ho, K. Wigglesworth, J. Eppig, R. Schultz
- Biology, Medicine
- Molecular reproduction and development
- 1 June 1995
KSOM/AA provides an environment in which preimplantation mouse embryos can undergo development that is quantitatively similar to that occurring in vivo, as compared to development supported by KSOM without amino acids. Expand
Evidence that Weakened Centromere Cohesion Is a Leading Cause of Age-Related Aneuploidy in Oocytes
- T. Chiang, F. E. Duncan, K. Schindler, R. Schultz, M. Lampson
- Biology, Medicine
- Current Biology
- 14 September 2010
It is shown that weakened chromosome cohesion is a leading cause of aneuploidy in oocytes in a natural aging mouse model, and a failure to effectively replace cohesin proteins that are lost from chromosomes during aging is demonstrated. Expand
LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes.
The data suggest that LY231514 is a novel classical antifolate, the antitumor activity of which may result from simultaneous and multiple inhibition of several key folate-requiring enzymes via its polyglutamated metabolites. Expand
Critical roles for Dicer in the female germline.
This work finds evidence that transposon-derived sequence elements may contribute to the metabolism of maternal transcripts through a Dicer-dependent pathway, and identifies Dicer as central to a regulatory network that controls oocyte gene expression programs and that promotes genomic integrity in a cell type notoriously susceptible to aneuploidy. Expand
Regulation of transcriptional activity during the first and second cell cycles in the preimplantation mouse embryo.
Transcription of endogenous genes in preimplantation 1- and 2-cell mouse embryos was determined by monitoring the incorporation of BrUTP by plasma membrane-permeabilized embryos and Trapoxin treatment, which induces histone hyperacetylation, enhances incorporation by 2- cell embryos 1.8-fold and suggests that histonehyperacetylations can relieve this repression. Expand
Age-associated increase in aneuploidy and changes in gene expression in mouse eggs.
Analysis of transcripts indicated that the strength of the spindle assembly checkpoint is weakened and that higher errors of microtubule-kinetochore interactions constitute part of molecular basis for the age-associated increase in aneuploidy in females. Expand
Transcript profiling during preimplantation mouse development.
Using microarrays, EASE identifies genes involved in critical biological processes that can be the subject of a more traditional hypothesis-driven approach and validates the hypothesis-generating approach. Expand
Selective loss of imprinting in the placenta following preimplantation development in culture
The results indicate that tissues of trophectoderm origin are unable to restore genomic imprints and suggest that mechanisms that safeguard imprinting might be more robust in the embryo than in the placenta. Expand
Apoptosis during mouse blastocyst formation: evidence for a role for survival factors including transforming growth factor alpha.
Results of these experiments suggest that endogenously produced growth factors may function as cell survival factors during preimplantation development. Expand