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GADD45A gene

Known as: GADD45, GROWTH ARREST- AND DNA DAMAGE-INDUCIBLE GENE GADD45, ALPHA, Growth Arrest and DNA-Damage-Inducible, Alpha Gene 
This gene plays a role in signal transduction and is induced in response to environmental stress. It is involved in apoptosis, DNA repair and… 
National Institutes of Health

Related topics

Related topics

6 relations
ApoptosisCell Cycle ControlDNA RepairGadd45a protein

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Deficiency in TR4 nuclear receptor abrogates Gadd45a expression and increases cytotoxicity induced by ionizing radiation
The testicular receptor 4 (TR4) is a member of the nuclear receptor superfamily that controls various biological activities. A… 
Highly Cited
2009
Highly Cited
2009
Analysis of 75 marketed pharmaceuticals using the GADD45a-GFP 'GreenScreen HC' genotoxicity assay.
The GADD45a-GFP (GreenScreen HC) reporter assay detects genotoxic damage in the human lymphoblastoid TK6 cell line and gives… 
2009
2009
Ligation or cross-linking of CD40 has different effects on AGS gastric cancer cells.
2007
2007
Incorporation of an internal ribosome entry site-dependent mechanism in arsenic-induced GADD45 alpha expression.
We have previously shown that trivalent arsenic (arsenite, As(3+)) is able to induce GADD45 alpha expression in human bronchial… 
2007
2007
Gadd45a regulates β-catenin distribution and maintains cell–cell adhesion/contact
Gadd45a, a growth arrest and DNA-damage gene, plays important roles in the control of cell cycle checkpoints, DNA repair and… 
2005
2005
Genomic Instability in Gadd45a-/- Cells is Coupled with S-Phase Checkpoint Defects
Gadd45a is a p53-regulated gene whose protein product, like p53, is involved in maintenanceof genome stability. Specifically… 
2003
2003
Differential UVC-induced gadd45 gene expression in xeroderma pigmentosum cells.
2002
2002
Inhibition of cell growth by NB1011 requires high thymidylate synthase levels and correlates with p53, p21, bax, and GADD45 induction.
NB1011, a phosphoramidate derivative of (E)-5-(2-bromovinyl)-2'-deoxyuridine, is a novel small molecule anticancer agent. NB1011… 
2000
2000
Gadd45 mutations are uncommon in human tumour cell lines
GADD45 is an evolutionarily conserved gene that encodes a small acidic, nuclear protein and is an example of a p53 responsive… 
1996
1996
A polymorphism but no mutations in the GADD45 gene in breast cancers
The p53 gene product is part of a pathway regulating growth arrest at the G1 checkpoint of the cell cycle. Mutation of other… 
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