Ftorafur
National Institutes of Health
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OBJECTIVES
To evaluate the clinical and cost-effectiveness of capecitabine and tegafur with uracil (UFT/LV) as first-line…
1. Painstaking progress in drug development is well illustrated by 5‐fluorouracil (5FU), originally designed 40 years ago as a…
Abstract A phase I and pharmacokinetic study of oral uracil, ftorafur, and leucovorin was performed in patients with advanced…
Background. UFT is a fixed‐ratio combination of uracil and Ftorafur, a prodrug that is absorbed orally and metabolized in vivo to…
Two hundred patients with node positive stage II breast cancer were randomised to four groups after radical mastectomy and…
A group of 243 patients with gastric cancer was subjected to a prospective randomized trial of adjuvant chemotherapy after…
The pharmacology of high-dose 1-(tetrahydro-2-furanyl)-5-fluorouracil (FT) has been studied by radiochemical and chromatographic…
Ftorafur, a possible sustained-release formulation of 5-fluorouracil, was administered to 27 patients with metastatic cancers…
Ftorafur, an active tumor drug, is less toxic than 5‐fluorouracil and was most effective in cancer of the breast and cancer of…