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Tegafur

Known as: 1-(Tetrahydro-2-furanyl)-5-fluorouracil, Tegafur [Chemical/Ingredient], 5-Fluoro-1-(tetrahydro-2-furanyl)-2,4-pyrimidinedione 
A congener of the antimetabolite fluorouracil with antineoplastic activity. Tegafur is a prodrug that is gradually converted to fluorouracil in the… 
National Institutes of Health

Related topics

Related topics

37 relations

Narrower (24)

3-FTACFM protocolBMFt protocolCOPU protocol

Broader (1)

Antimetabolites, Antineoplastic
In BloodNCIt Antineoplastic Agent Terminologyagonistsanalogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2001
Highly Cited
2001
Improved survival with oral administration of enteric‐coated tegafur/uracil for advanced stage IV‐A hepatocellular carcinoma
Background and Aims: There is currently no proven chemotherapy regimen for hepatocellular carcinoma (HCC). The principal… 
Highly Cited
1995
Highly Cited
1995
Postoperative prophylactic lipiodolization reduces the intrahepatic recurrence of hepatocellular carcinoma.
1990
1990
Postgastrectomy prescription of mitomycin C and UFT for patients with stage IV gastric carcinoma.
Review
1987
Review
1987
Clinical efficacy of lentinan on patients with stomach cancer: end point results of a four-year follow-up survey.
Highly Cited
1984
Highly Cited
1984
Postoperative adjuvant chemotherapy for gastric carcinoma analysis of data on 1805 patients followed for 5 years
The effectiveness of combination chemotherapy with mitomycin‐C (MMC) plus Futraful (N1‐(2′‐tetrahydrofuryl)‐5‐fluorouracil) for… 
Highly Cited
1983
Highly Cited
1983
Phase I-II studies of oral tegafur (ftorafur).
A total of 65 patients with advanced colorectal or breast cancer were given oral tegafur in the phase I study. Of these, 28… 
1979
1979
Effect of Coadministration of Uracil or Cytosine on the Antitumor Activity of Clinical Doses of 1-(2-Tetrahydrofuryl)-5-Fluorouracil and Level of 5-Fluorouracil in Rodents
Highly Cited
1978
Highly Cited
1978
Disposition and metabolism of 1-(tetrahydro-2-furanyl)-5-fluorouracil (ftorafur) in humans.
The pharmacology of high-dose 1-(tetrahydro-2-furanyl)-5-fluorouracil (FT) has been studied by radiochemical and chromatographic… 
1978
1978
Experimental chemotherapy of carcinoma of the human stomach and colon serially transplanted in nude mice.
Human gastric and colon carcinomas serially transplantable in nude mice, designated as St-4, St-15, and Co-3, were used for… 
1976
1976
Antitumor activity of 1-hexylcarbamoyl-5-fluorouracil in a variety of experimental tumors.
Antitumor activity of 1-hexylcarbamoyl-5-fluorouracil against various tumors was examined. Therapeutic ratio (ILSmax/ILS30) in L… 
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