Tegafur

Known as: 1-(Tetrahydro-2-furanyl)-5-fluorouracil, Tegafur [Chemical/Ingredient], 5-Fluoro-1-(tetrahydro-2-furanyl)-2,4-pyrimidinedione 
A congener of the antimetabolite fluorouracil with antineoplastic activity. Tegafur is a prodrug that is gradually converted to fluorouracil in the… (More)

Topic mentions per year

Topic mentions per year

1976-2017
05010019762017

Papers overview

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Highly Cited
2006
Highly Cited
2006
PURPOSE The primary aim of this study was to compare the relative efficacy of oral uracil and tegafur (UFT) plus leucovorin (LV… (More)
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Highly Cited
2005
Highly Cited
2005
PURPOSE Recent clinical trials have shown the efficacy of platinum-based adjuvant chemotherapy for completely resected non-small… (More)
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Highly Cited
2004
Highly Cited
2004
BACKGROUND In a previous phase 3 trial of adjuvant chemotherapy after resection of non-small-cell lung cancer, a combination of… (More)
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Highly Cited
2003
Highly Cited
2003
PURPOSE To compare fluorouracil (FU) alone with FU plus cisplatin (FP) and with uracil and tegafur plus mitomycin (UFTM) for… (More)
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Highly Cited
2002
Highly Cited
2002
PURPOSE This phase III study was designed to demonstrate equivalence in survival of oral uracil/tegafur (UFT) and oral leucovorin… (More)
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Highly Cited
2000
Highly Cited
2000
Tegafur is a prodrug of 5-fluorouracil (5-FU) consisting of a new class of oral chemotherapeutic agents, tegafur/uracil and S-1… (More)
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Highly Cited
1998
Highly Cited
1998
S-1 is a novel oral anticancer drug, composed of tegafur (FT), gimestat (CDHP) and otastat potassium (Oxo) in a molar ratio of 1… (More)
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Highly Cited
1996
Highly Cited
1996
We have focused our attention on the development of a novel form of a tegafur-based [FT; a prodrug of 5-fluorouracil (5-FU… (More)
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Highly Cited
1993
Highly Cited
1993
The possibility of decreasing the gastrointestinal (GI) toxic effects of 5-fluorouracil (5-FU) on the digestive tract such as its… (More)
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Highly Cited
1985
Highly Cited
1985
A total of 850 patients with hepatocellular carcinoma seen during the last 8 years were analyzed retrospectively for survival in… (More)
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