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Relationship between Development of Diarrhea and the Concentration of SN‐38, an Active Metabolite of CPT‐11, in the Intestine and the Blood Plasma of Athymic Mice Following Intraperitoneal
Severe diarrhea occurred during daily intraperitoneal administration of 7‐ethyl‐10‐[4‐(l‐piperidino)‐l‐piperidino]carbonyloxycamptothecin (CPT‐11) at a dose of 50 mg/kg in athymic mouse. SerialExpand
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Metabolism of terephthalic acid. 3. Absorption of terephthalic acid from gastrointestinal tract and detection of its metabolites.
The absorption of terephthalic acid (TPA) from gastrointestinal tract and its metabolites in urine were studied with radioactive TPA (carboxyl-14C compound). Terephthalic acid was absorbed mainlyExpand
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Clonogenic patterns of human pulmonary adenocarcinoma cell lines (PC-9, PC-13 and PC-14) and how they influence the results of test for chemosensitivity to cisplatin in the human tumor clonogenic
The clonogenic patterns of three human pulmonary adenocarcinoma cell lines (PC-9, PC-13 and PC-14) were studied by human tumor clonogenic assay (HTCA), and factors which could influence the resultsExpand
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Toxicity of terephthalic acid.
The acute toxicity of terephthalic acid and its sodium salt, the effect of terephthalic acid administration on liver and renal functions, and the chemical composition of blood plasma were studied.Expand
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In vivo antitumor activity of multiple injections of recombinant interleukin 2, alone and in combination with three different types of recombinant interferon, on various syngeneic murine tumors.
We have used several transplantable experimental murine tumors to evaluate the potentiation of antitumor activity by a combination of human recombinant interleukin 2 (rHIL2) and recombinantExpand
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Antitumor activity of berberrubine derivatives.
The antitumor activity of berberine, berberrubine, and their derivatives against sarcoma-180 ascites was determined by the total packed cell volume method. Berbine and tetrahydroberberine derivativesExpand
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Effect of chemotherapy on natural-killer activity and antibody-dependent cell-mediated cytotoxicity in carcinoma of the lung.
The effect of chemotherapy on natural killer (NK) activity and antibody-dependent cell-mediated cytotoxicity (ADCC) in 15 advanced carcinomas of the lung was examined with regard to the drug, dose,Expand
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Mechanism of inhibition of phosphoribosylation of 5-fluorouracil by purines.
The mechanism of the abolishment of the cytotoxicity of 5-flurouracil by purines in L5178Y cells was determined by using phosphoribosylation enzymes for both 5-fluorouracil and hypoxanthine.Expand
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Improved colony formation of cultured retinoblastoma cells.
The effect of various components of three semi-solid media on colony formation in two representative retinoblastoma cell lines, Y-79 and WERI, was determined. Diethylaminoethyl dextran was found toExpand
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