Focal Adhesion Protein-Tyrosine Kinases

Known as: Focal Adhesion Kinase, Focal Adhesion Protein-Tyrosine Kinases [Chemical/Ingredient], Focal Adhesion Protein-Tyrosine Kinase Family 
A family of non-receptor, PROLINE-rich protein-tyrosine kinases.
National Institutes of Health

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Focal Adhesion Kinase 1PTK2 protein, human
In BloodPTK2 geneProcess of secretionantagonists & inhibitors
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Papers overview

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Highly Cited
2005
Highly Cited
2005
Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase
Imaging studies implicate microtubule targeting of focal adhesions in focal adhesion disassembly, although the molecular… (More)
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Review
2004
Review
2004
Focal adhesion regulation of cell behavior.
Focal adhesions lie at the convergence of integrin adhesion, signaling and the actin cytoskeleton. Cells modify focal adhesions… (More)
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Highly Cited
2004
Highly Cited
2004
FAK–Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly
Cell migration is a complex, highly regulated process that involves the continuous formation and disassembly of adhesions… (More)
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Review
2003
Review
2003
Focal adhesion kinase: the first ten years.
The protein tyrosine kinase focal adhesion kinase (FAK) plays a prominent role in integrin signaling. FAK activation… (More)
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Highly Cited
2001
Highly Cited
2001
Taking cell-matrix adhesions to the third dimension.
Adhesions between fibroblastic cells and extracellular matrix have been studied extensively in vitro, but little is known about… (More)
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Highly Cited
1999
Highly Cited
1999
Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration.
FAK localizes to sites of transmembrane integrin receptor clustering and facilitates intracellular signaling events. FAK-null… (More)
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Highly Cited
1997
Highly Cited
1997
Fluid shear stress activation of focal adhesion kinase. Linking to mitogen-activated protein kinases.
Shear stress, the tangential component of hemodynamic forces, activates the extracellular signal-regulated kinase (ERK) and c-Jun… (More)
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Highly Cited
1996
Highly Cited
1996
Phosphorylation of tyrosine 397 in focal adhesion kinase is required for binding phosphatidylinositol 3-kinase.
We have shown previously that cell adhesion or platelet-derived growth factor (PDGF) promotes the in vivo association of focal… (More)
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Highly Cited
1995
Highly Cited
1995
Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors.
The focal adhesion kinase (FAK) gene encodes a tyrosine kinase (p125FAK) thought to be involved in signal transduction pathways… (More)
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Highly Cited
1994
Highly Cited
1994
Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase
THE cytoplasmic focal adhesion protein-tyrosine kinase (FAK) localizes with surface integrin receptors at sites where cells… (More)
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