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Focal Adhesion Protein-Tyrosine Kinases

Known as: Focal Adhesion Kinase, Focal Adhesion Protein-Tyrosine Kinases [Chemical/Ingredient], Focal Adhesion Protein-Tyrosine Kinase Family 
A family of non-receptor, PROLINE-rich protein-tyrosine kinases.
National Institutes of Health

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Focal Adhesion Kinase 1PTK2 protein, human
In BloodPTK2 geneProcess of secretionantagonists & inhibitors

Papers overview

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Highly Cited
2010
Highly Cited
2010
3D collagen type I matrix inhibits the antimigratory effect of doxorubicin
BackgroundThe cell microenvironment, especially extracellular matrix proteins, plays an important role in tumor cell response to… 
Highly Cited
2009
Highly Cited
2009
Absolute quantification of phosphorylation on the kinase activation loop of cellular focal adhesion kinase by stable isotope dilution liquid chromatography/mass spectrometry.
A vital point of convergence for many signaling pathways at cellular focal adhesions is the interaction of two nonreceptor… 
Highly Cited
2004
Highly Cited
2004
Squamous Cell Carcinoma Cell Aggregates Escape Suspension-induced, p53-mediated Anoikis
Resistance to anoikis, or apoptosis triggered by detachment from the extracellular matrix (ECM), lengthens the survival of… 
Highly Cited
2001
Highly Cited
2001
PTEN-independent induction of caspase-mediated cell death and reduced invasion by the focal adhesion targeting domain (FAT) in human astrocytic brain tumors which highly express focal adhesion kinase…
Increased expression of focal adhesion kinase (FAK) was consistently observed in low- and high-grade astrocytomas and during… 
Highly Cited
1999
Highly Cited
1999
Divergent Signaling Pathways Link Focal Adhesion Kinase to Mitogen-activated Protein Kinase Cascades
Stimulation of a number of cell surface receptors, including integrins and G protein-coupled receptors, results in the activation… 
Highly Cited
1999
Highly Cited
1999
Dephosphorylation of Focal Adhesion Kinase (FAK) and Loss of Focal Contacts Precede Caspase-mediated Cleavage of FAK during Apoptosis in Renal Epithelial Cells*
The relationship between focal adhesion protein (FAK) activity and loss of cell-matrix contact during apoptosis is not entirely… 
Highly Cited
1998
Highly Cited
1998
Growth Hormone Stimulates the Tyrosine Phosphorylation and Association of p125 Focal Adhesion Kinase (FAK) with JAK2
We have demonstrated that growth hormone (GH) activates focal adhesion kinase (FAK), and this activation results in the tyrosine… 
Highly Cited
1998
Highly Cited
1998
Insulin‐like growth factor‐I‐mediated survival from Anoikis: Role of cell aggregation and focal adhesion kinase
Anoikis is a form of cell death that occurs when cells are denied attachment to the extra‐cellular matrix. Using p6 cells, that… 
Highly Cited
1997
Highly Cited
1997
RAFTK, a Novel Member of the Focal Adhesion Kinase Family, Is Phosphorylated and Associates with Signaling Molecules upon Activation of Mature T Lymphocytes
The related adhesion focal tyrosine kinase (RAFTK), a recently discovered member of the focal adhesion kinase family, has… 
Highly Cited
1996
Highly Cited
1996
The Related Adhesion Focal Tyrosine Kinase Forms a Complex with Paxillin in Hematopoietic Cells*
Related adhesion focal tyrosine kinase (RAFTK), also known as proline-rich tyrosine kinase 2 and cellular adhesion kinase β, has… 
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