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PTK2 protein, human

Known as: Focal Adhesion Kinase-Related Nonkinase, FAK1, Focal Adhesion Kinase 1 
Focal adhesion kinase 1 (1052 aa, ~119 kDa) is encoded by the human PTK2 gene. This protein is involved in signaling, tyrosine phosphorylation, cell… 
National Institutes of Health

Related topics

Related topics

30 relations
Agrin PathwayAngiogenesis PathwayAngiotensin II Signaling PathwayApoptosis

Broader (2)

Focal Adhesion Kinase 1Focal Adhesion Protein-Tyrosine Kinases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2005
2005
Adhesion-dependent activation of CaMKII and regulation of ERK activation in vascular smooth muscle.
Cell adhesion-dependent activation of ERK1/2 has been linked functionally to focal adhesion dynamics. We previously reported that… 
Highly Cited
2002
Highly Cited
2002
Antiapoptotic action of focal adhesion kinase (FAK) against ionizing radiation.
Focal adhesion kinase (FAK) has an antiapoptotic role in anchorage-dependent cells via an unknown mechanism. To elucidate the… 
2001
2001
PKC-dependent activation of FAK and src induces tyrosine phosphorylation of Cas and formation of Cas-Crk complexes.
SH-SY5Y neuroblastoma cells are a well-characterized model for studying the induction of neuronal differentiation. TPA treatment… 
Highly Cited
2001
Highly Cited
2001
PTEN-independent induction of caspase-mediated cell death and reduced invasion by the focal adhesion targeting domain (FAT) in human astrocytic brain tumors which highly express focal adhesion kinase…
Increased expression of focal adhesion kinase (FAK) was consistently observed in low- and high-grade astrocytomas and during… 
2000
2000
Regulation of Neutrophil Adhesion by Pituitary Growth Hormone Accompanies Tyrosine Phosphorylation of Jak2, p125FAK, and Paxillin1
Neutrophil adhesion is fundamentally important during the onset of inflammatory responses. The adhesion signaling pathways… 
1998
1998
Endothelial cell spreading on type IV collagen and spreading-induced FAK phosphorylation is regulated by Ca2+ influx.
The interaction of endothelial cells with their basement membrane and local stroma is highly regulated. The observation that CAI… 
1994
1994
Lymphocyte antigen receptor activation of a focal adhesion kinase-related tyrosine kinase substrate.
One of the earliest responses of T and B lymphocytes to stimulation through their antigen receptors is the activation of protein… 
Highly Cited
1994
Highly Cited
1994
Integrin-mediated signal transduction in human endothelial cells: analysis of tyrosine phosphorylation events.
Adhesion of human umbilical endothelial cells to fibronectin resulted in increased tyrosine phosphorylation of a group of… 
Highly Cited
1994
Highly Cited
1994
Structurally distinct disintegrins contortrostatin and multisquamatin differentially regulate platelet tyrosine phosphorylation.
Tyrosine phosphorylation of multiple platelet proteins is regulated by the integrin alpha IIb beta 3. In order to further examine… 
Highly Cited
1981
Highly Cited
1981
Nucleated assembly of mitotic microtubules in living PTK2 cells after release from nocodazole treatment.
The reassembly of microtubules is described in mitotic cells after release from nocodazole-induced block. The formation of… 
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