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PTK2 protein, human

Known as: Focal Adhesion Kinase-Related Nonkinase, FAK1, Focal Adhesion Kinase 1 
Focal adhesion kinase 1 (1052 aa, ~119 kDa) is encoded by the human PTK2 gene. This protein is involved in signaling, tyrosine phosphorylation, cell… 
National Institutes of Health

Related topics

Related topics

30 relations
Agrin PathwayAngiogenesis PathwayAngiotensin II Signaling PathwayApoptosis

Broader (2)

Focal Adhesion Kinase 1Focal Adhesion Protein-Tyrosine Kinases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Type I Phosphatidylinositol Phosphate Kinase Beta Regulates Focal Adhesion Disassembly by Promoting β1 Integrin Endocytosis
ABSTRACT Cell migration requires the regulated disassembly of focal adhesions, but the underlying mechanisms remain poorly… 
Highly Cited
2006
Highly Cited
2006
Weak Expression of Focal Adhesion Kinase (pp125FAK) in Patients with Cervical Cancer Is Associated with Poor Disease Outcome
Purpose: The pp125 focal adhesion kinase (FAK) plays a pivotal role in tumor cell signaling. FAK expression has been linked to… 
Highly Cited
2002
Highly Cited
2002
Antiapoptotic action of focal adhesion kinase (FAK) against ionizing radiation.
Focal adhesion kinase (FAK) has an antiapoptotic role in anchorage-dependent cells via an unknown mechanism. To elucidate the… 
Highly Cited
2001
Highly Cited
2001
Loss of focal adhesion kinase (FAK) inhibits epidermal growth factor receptor-dependent migration and induces aggregation of nh(2)-terminal FAK in the nuclei of apoptotic glioblastoma cells.
In glioblastoma cells, inhibition of focal adhesion kinase (FAK) by the focal adhesion targeting domain attenuated epidermal… 
Highly Cited
2001
Highly Cited
2001
PTEN-independent induction of caspase-mediated cell death and reduced invasion by the focal adhesion targeting domain (FAT) in human astrocytic brain tumors which highly express focal adhesion kinase…
Increased expression of focal adhesion kinase (FAK) was consistently observed in low- and high-grade astrocytomas and during… 
2001
2001
PKC-dependent activation of FAK and src induces tyrosine phosphorylation of Cas and formation of Cas-Crk complexes.
SH-SY5Y neuroblastoma cells are a well-characterized model for studying the induction of neuronal differentiation. TPA treatment… 
Highly Cited
1995
Highly Cited
1995
T cell receptor- and beta 1 integrin-mediated signals synergize to induce tyrosine phosphorylation of focal adhesion kinase (pp125FAK) in human T cells
The beta 1 subfamily of integrins is thought to play an important role in both the adhesion/migration and proliferation… 
1994
1994
Lymphocyte antigen receptor activation of a focal adhesion kinase-related tyrosine kinase substrate.
One of the earliest responses of T and B lymphocytes to stimulation through their antigen receptors is the activation of protein… 
Highly Cited
1994
Highly Cited
1994
Integrin-mediated signal transduction in human endothelial cells: analysis of tyrosine phosphorylation events.
Adhesion of human umbilical endothelial cells to fibronectin resulted in increased tyrosine phosphorylation of a group of… 
Highly Cited
1981
Highly Cited
1981
Nucleated assembly of mitotic microtubules in living PTK2 cells after release from nocodazole treatment.
The reassembly of microtubules is described in mitotic cells after release from nocodazole-induced block. The formation of… 
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