PTK2 protein, human

Known as: Focal Adhesion Kinase-Related Nonkinase, FAK1, Focal Adhesion Kinase 1 
Focal adhesion kinase 1 (1052 aa, ~119 kDa) is encoded by the human PTK2 gene. This protein is involved in signaling, tyrosine phosphorylation, cell… (More)
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
Cell spreading, adhesion and remodelling of the extracellular matrix (ECM) involve bi-directional signalling and physical… (More)
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Highly Cited
2003
Highly Cited
2003
The serine/threonine kinase Cdk5 plays an essential role in neuronal positioning during corticogenesis, but the underlying… (More)
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Highly Cited
2000
Highly Cited
2000
Focal adhesion kinase (FAK) is activated and localized at focal adhesions upon cell adhesion to extracellular matrices. Cells… (More)
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Highly Cited
1999
Highly Cited
1999
FAK localizes to sites of transmembrane integrin receptor clustering and facilitates intracellular signaling events. FAK-null… (More)
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Highly Cited
1996
Highly Cited
1996
It has been proposed that the focal adhesion kinase (FAK) mediates focal adhesion formation through tyrosine phosphorylation… (More)
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Highly Cited
1995
Highly Cited
1995
The integrins have recently been implicated in signal transduction. A likely mediator of integrin signaling is focal adhesion… (More)
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Highly Cited
1995
Highly Cited
1995
Paxillin, a focal-adhesion-associated protein, becomes phosphorylated in response to a number of stimuli which also induce the… (More)
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Highly Cited
1995
Highly Cited
1995
Extracellular matrix controls capillary endothelial cell sensitivity to soluble mitogens by binding integrin receptors and… (More)
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Highly Cited
1995
Highly Cited
1995
The focal adhesion kinase (FAK) gene encodes a tyrosine kinase (p125FAK) thought to be involved in signal transduction pathways… (More)
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Highly Cited
1992
Highly Cited
1992
We have investigated mechanisms involved in integrin-mediated signal transduction in platelets by examining integrin-dependent… (More)
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