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FAK localizes to sites of transmembrane integrin receptor clustering and facilitates intracellular signaling events. FAK-null… Expand FOCAL adhesion kinase1,2 (pp125FAK) is a member of a growing family of structurally distinct protein tyrosine kinases that… Expand Integrin receptors mediate cell adhesion, signal transduction, and cytoskeletal organization. How a single transmembrane receptor… Expand The integrins have recently been implicated in signal transduction. A likely mediator of integrin signaling is focal adhesion… Expand The focal adhesion kinase (FAK) gene encodes a tyrosine kinase (p125FAK) thought to be involved in signal transduction pathways… Expand The phosphorylation of protein tyrosine kinases (PTKs) on tyrosine residues is a critical regulatory event that modulates… Expand Integrins can function as signal-transducing receptors capable of modulating cell growth and gene expression (Juliano, R. L., and… Expand Cells in culture reveal high levels of protein tyrosine phosphorylation in their focal adhesions, the regions where cells adhere… Expand We have investigated mechanisms involved in integrin-mediated signal transduction in platelets by examining integrin-dependent… Expand We have recently shown that changes in tyrosine phosphorylation of a 130-kDa protein(s) (pp130) may be involved in integrin… Expand