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PTK2 protein, human

Known as: Focal Adhesion Kinase-Related Nonkinase, FAK1, Focal Adhesion Kinase 1 
Focal adhesion kinase 1 (1052 aa, ~119 kDa) is encoded by the human PTK2 gene. This protein is involved in signaling, tyrosine phosphorylation, cell… Expand
National Institutes of Health

Papers overview

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Highly Cited
1999
Highly Cited
1999
FAK localizes to sites of transmembrane integrin receptor clustering and facilitates intracellular signaling events. FAK-null… Expand
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Highly Cited
1996
Highly Cited
1996
FOCAL adhesion kinase1,2 (pp125FAK) is a member of a growing family of structurally distinct protein tyrosine kinases that… Expand
Highly Cited
1995
Highly Cited
1995
Integrin receptors mediate cell adhesion, signal transduction, and cytoskeletal organization. How a single transmembrane receptor… Expand
Highly Cited
1995
Highly Cited
1995
The integrins have recently been implicated in signal transduction. A likely mediator of integrin signaling is focal adhesion… Expand
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Highly Cited
1995
Highly Cited
1995
The focal adhesion kinase (FAK) gene encodes a tyrosine kinase (p125FAK) thought to be involved in signal transduction pathways… Expand
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Highly Cited
1994
Highly Cited
1994
The phosphorylation of protein tyrosine kinases (PTKs) on tyrosine residues is a critical regulatory event that modulates… Expand
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Highly Cited
1994
Highly Cited
1994
Integrins can function as signal-transducing receptors capable of modulating cell growth and gene expression (Juliano, R. L., and… Expand
Highly Cited
1992
Highly Cited
1992
Cells in culture reveal high levels of protein tyrosine phosphorylation in their focal adhesions, the regions where cells adhere… Expand
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Highly Cited
1992
Highly Cited
1992
We have investigated mechanisms involved in integrin-mediated signal transduction in platelets by examining integrin-dependent… Expand
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Highly Cited
1992
Highly Cited
1992
We have recently shown that changes in tyrosine phosphorylation of a 130-kDa protein(s) (pp130) may be involved in integrin… Expand