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CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum.
Compared with the wild type, mouse embryonic fibroblasts derived from chop -/- animals exhibited significantly less programmed cell death when challenged with agents that perturb ER function, and the proximal tubule epithelium of chop -/+ animals exhibited fourfold lower levels of TUNEL-positive cells, and significantly less evidence for subsequent regeneration. Expand
Kidney injury molecule-1: a tissue and urinary biomarker for nephrotoxicant-induced renal injury.
The upregulation of expression of Kim-1 and its presence in the urine in response to exposure to various types of nephrotoxicants suggest that this protein may serve as a general biomarker for tubular injury and repair processes. Expand
35H, a Sequence Isolated as a Protein Kinase C Binding Protein, Is a Novel Member of the Adducin Family (*)
Results indicate that 35H is a new, widely expressed form of adducin capable of forming heterodimers with α-adducin and proposes naming this ad Ducin homologue -adducIn. Expand
Endoplasmic Reticulum Chaperones GRP78 and Calreticulin Prevent Oxidative Stress, Ca2+ Disturbances, and Cell Death in Renal Epithelial Cells*
The data support a model in which induction of ER stress proteins prevents disturbances of intracellular Ca2+ homeostasis, thus uncoupling toxicant exposure from oxidative stress and cell death, and support the role of ER chaperones of the GRP family in tolerance. Expand
A purified cysteine conjugate beta-lyase from rat kidney cytosol. Requirement for an alpha-keto acid or an amino acid oxidase for activity and identity with soluble glutamine transaminase K.
The data show that rat kidney cytosolic glutamine transaminase K catalyzes both a beta-elimination and a transamination reaction with DCVC when alpha-keto-gamma-methiolbutyrate is present and that amino acid oxidase and alpha- keto-Gamma-Methiol butyrate stimulate the enzyme activity by providing amino acceptors. Expand
Quantitative and Systems Pharmacology in the Post-genomic Era : New Approaches to Discovering Drugs and Understanding Therapeutic
In a situation where the overall behavior of the system depends on many different components, horizontal integration synthesizes a composite model from several components having the same spatialExpand
The future of drug safety testing: expanding the view and narrowing the focus.
An expanded view on the application of predictive strategies and technologies to early safety decisions and suggestions to narrow the focus for improving preclinical safety testing to the problems that contribute most to adverse drug reactions are offered. Expand
The role of glutathione conjugate metabolism and cysteine conjugate beta-lyase in the mechanism of S-cysteine conjugate toxicity in LLC-PK1 cells.
The data suggest that cysteine conjugate beta-lyase in LLC-PK1 cells may be regulated by transamination, and measurement of lyase activity in some systems may require the presence of alpha-ketoacids. Expand
CHOP links endoplasmic reticulum stress to NF-κB activation in the pathogenesis of nonalcoholic steatohepatitis
During metabolic stress, the UPR transcription factor CHOP activates NF-κB through a pathway involving IRAK2 expression, resulting in hepatocyte secretion of cytokines IL-8 and TNFα, which triggerExpand
Activation of Heat Shock Factor by Alkylating Agents Is Triggered by Glutathione Depletion and Oxidation of Protein Thiols (*)
Alkylation of proteins is insufficient to activate hsp70 transcription and DNA binding of HSF1, however, cellular thiol-disulfide redox status and formation of disulfide linked aggregates of cellular proteins are linked to HSF 1 activation and hsp 70 transcriptional activation. Expand