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Fluorodeoxyuridylate

Known as: FdUMP, 5-Fluoro-2'-Deoxyuridine-5'-Monophosphate, Fluorodeoxyuridylate [Chemical/Ingredient] 
5-Fluoro-2'-deoxyuridylate. An inhibitor of thymidylate synthetase. Formed from 5-fluorouracil or 5-fluorodeoxyuridine.
National Institutes of Health

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5-fluorouridine diphosphate glucoseT 506
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

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Highly Cited
2001
Highly Cited
2001
Characterization of a thymidylate synthase (TS)-inducible cell line: a model system for studying sensitivity to TS- and non-TS-targeted chemotherapies.
Thymidylate synthase (TS) is responsible for the de novo synthesis of thymidylate, which is required for DNA synthesis and repair… 
1998
1998
Effect of the combined treatment with 5-fluorouracil, gamma-interferon or folinic acid on carcinoembryonic antigen expression in colon cancer cells.
5-Fluorouracil (5-FU) and human recombinant gamma-interferon (gamma-IFN) were found to increase the expression of… 
Highly Cited
1990
Highly Cited
1990
Stereochemical mechanism of action for thymidylate synthase based on the X-ray structure of the covalent inhibitory ternary complex with 5-fluoro-2'-deoxyuridylate and 5,10-methylenetetrahydrofolate.
Highly Cited
1987
Highly Cited
1987
Pyrimethamine resistant Plasmodium falciparum: overproduction of dihydrofolate reductase by a gene duplication.
Highly Cited
1981
Highly Cited
1981
Methods for the complete analysis of 5-fluorouracil metabolites in cell extracts.
Highly Cited
1980
Highly Cited
1980
Metabolism and biological activity of 5'-deoxy-5-fluorouridine, a novel fluoropyrimidine.
5'-Deoxy-5-fluorouridine (5'-dFUrd; Roche 21-9738) is a recently synthesized antineoplastic agent with therapeutic potential. The… 
Highly Cited
1980
Highly Cited
1980
Induction of mitotic recombination in yeast by starvation for thymine nucleotides.
The biosynthesis of thymine nucleotides in Saccharomyces cerevisiae can be inhibited either by genetic lesions in the structural… 
Highly Cited
1979
Highly Cited
1979
Biochemical determinants of tumor sensitivity to 5-fluorouracil: ultrasensitive methods for the determination of 5-fluoro-2'-deoxyuridylate, 2'-deoxyuridylate, and thymidylate synthetase.
Techniques have been developed to measure FdUMP, the active metabolite of 5-FUra; thymidylate synthetase (TMP synthase; 5,10… 
Highly Cited
1979
Highly Cited
1979
Assay of intracellular free and macromolecular-bound metabolites of 5-fluorodeoxyuridine and 5-fluorouracil.
Methods have been developed to assay several aspects of 5-fluoro-2'-deoxyuridine and 5-fluorouracil metabolism in tissue culture… 
Highly Cited
1976
Highly Cited
1976
Factors affecting substrate binding in Lactobacillus casei thymidylate synthetase as studied by equilibrium dialysis.
The binding of deoxynucleoside 5'-monophosphates and various folate derivatives to Lactobacillus casei thymidylate synthetase was… 
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