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Structure and Function of G Protein Coupled Receptors
TLDR
This review summarizes the current knowledge of the molecular mechanisms by which the GPC-Rs activate second messenger systems, and it addresses their regulation and structure. Expand
Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory
TLDR
The results identify regulatory DRD2 polymorphisms that modify mRNA expression and splicing and working memory pathways that are associated with greater activity of striatum and prefrontal cortex measured with fMRI and with reduced performance in working memory and attentional control tasks in healthy humans. Expand
Intronic polymorphism in CYP3A4 affects hepatic expression and response to statin drugs
TLDR
The results indicate that intron 6 SNP rs35599367 markedly affects expression of CYP3A4 and could serve as a biomarker for predicting response to CYP2A4-metabolized drugs. Expand
Allelic Expression Imbalance of Human mu Opioid Receptor (OPRM1) Caused by Variant A118G*
TLDR
Results indicate that OPRM1-G118 is a functional variant with deleterious effects on both mRNA and protein yield, and clarifying the functional relevance of polymorphisms associated with susceptibility to a complex disorder such as drug addiction provides a foundation for clinical association studies. Expand
Strategies and methods for research on sex differences in brain and behavior.
TLDR
Methods and procedures are described to assist scientists new to the field in designing and conducting experiments to investigate sex differences in research involving both laboratory animals and humans. Expand
ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma.
TLDR
It is shown that ABCB5, which functions as a determinant of membrane potential and regulator of cell fusion in physiologic skin progenitor cells, is expressed in clinical malignant melanoma tumors and preferentially marks a subset of hyperpolarized, CD133+ stem cell phenotype-expressing tumor cells in malignant sunscreen cultures and clinical melanomas. Expand
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP3A5 Genotype and Tacrolimus Dosing
TLDR
Individuals who express CYP3A5 (extensive and intermediate metabolizers) generally have decreased dose‐adjusted trough concentrations of tacrolimus as compared with those who are CYP 3A5 nonexpressers (poor metabolizers), possibly delaying achievement of target blood concentrations. Expand
Potential role of pharmacogenomics in reducing adverse drug reactions: a systematic review.
TLDR
The results suggest that drug therapy based on individuals' genetic makeups may result in a clinically important reduction in adverse outcomes and serve as a foundation for further research on how pharmacogenomics can reduce the incidence of adverse reactions and on the resulting clinical, societal, and economic implications. Expand
Inverse agonists and neutral antagonists at µ opioid receptor (MOR): possible role of basal receptor signaling in narcotic dependence
TLDR
In an acute and chronic mouse model of morphine‐induced dependence, 6β‐naltrexol caused significantly reduced withdrawal jumping compared to naloxone and naltrexone, at doses effective in blocking morphine antinociception, which supports the hypothesis that n aloxone‐induced withdrawal symptoms result at least in part from suppression of basal signaling activity of MOR in morphine‐dependent animals. Expand
Allelic mRNA expression of X-linked monoamine oxidase a (MAOA) in human brain: dissection of epigenetic and genetic factors.
TLDR
Allelic mRNA expression is affected by genetic and epigenetic events, both with the potential to modulate biogenic amine tone in the CNS. Expand
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