Factor XI

Known as: Antecedent, Plasma Thromboplastin, Plasma Thromboplastin Antecedent, XI, Coagulation Factor 
Stable blood coagulation factor involved in the intrinsic pathway. The activated form XIa activates factor IX to IXa. Deficiency of factor XI is… (More)
National Institutes of Health

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Highly Cited
2015
Highly Cited
2015
BACKGROUND Experimental data indicate that reducing factor XI levels attenuates thrombosis without causing bleeding, but the role… (More)
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Highly Cited
2010
Highly Cited
2010
Mice lacking factor XII (fXII) or factor XI (fXI) are resistant to experimentally-induced thrombosis, suggesting fXIIa activation… (More)
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Highly Cited
2009
Highly Cited
2009
The protease thrombin is required for normal hemostasis and pathologic thrombogenesis. Since the mechanism of coagulation factor… (More)
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Highly Cited
1999
Highly Cited
1999
Thrombin can activate factor XI in the presence of dextran sulfate or sulfatides. However, a physiological cofactor for thrombin… (More)
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Highly Cited
1998
Highly Cited
1998
Recent in vitro studies have shown that fibrinolytic activity may be attenuated by a thrombin-activatable fibrinolysis inhibitor… (More)
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Highly Cited
1997
Highly Cited
1997
Recently, it has been shown that Factor XI can be activated by thrombin, and that Factor XIa significantly contributes to the… (More)
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Highly Cited
1991
Highly Cited
1991
Coagulation factor XI is activated in vitro by factor XIIa in the presence of high molecular weight kininogen (HMWK) and a… (More)
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Highly Cited
1991
Highly Cited
1991
Human blood coagulation factor XI was activated by either autoactivation or thrombin. These reactions occurred only in the… (More)
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Highly Cited
1977
Highly Cited
1977
Factor XI and high molecular weight kininogen were found associated in normal human plasma at mol wt 380,000 as assessed by gel… (More)
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Highly Cited
1977
Highly Cited
1977
Human blood coagulation Factor XI was purified in 20% yield from plasma by ion exchange chromatography. The specific clotting… (More)
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