Factor XI

Known as: Antecedent, Plasma Thromboplastin, Plasma Thromboplastin Antecedent, XI, Coagulation Factor 
Stable blood coagulation factor involved in the intrinsic pathway. The activated form XIa activates factor IX to IXa. Deficiency of factor XI is… (More)
National Institutes of Health

Related topics

Related topics

21 relations
Activated Partial Thromboplastin Time measurementCoagulantsCoagulation factor XI Ag:ACnc:Pt:PPP:Qn:IACoagulation factor XI activity:ACnc:Pt:PPP:Qn:Chromo
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Broader (3)

Blood Coagulation FactorSerine EndopeptidasesSerine Proteases

Narrower (1)

Factor XIa

Papers overview

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Highly Cited
2015
Highly Cited
2015
Factor XI antisense oligonucleotide for prevention of venous thrombosis.
BACKGROUND Experimental data indicate that reducing factor XI levels attenuates thrombosis without causing bleeding, but the role… (More)
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Highly Cited
2010
Highly Cited
2010
A role for factor XIIa-mediated factor XI activation in thrombus formation in vivo.
Mice lacking factor XII (fXII) or factor XI (fXI) are resistant to experimentally-induced thrombosis, suggesting fXIIa activation… (More)
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Highly Cited
2009
Highly Cited
2009
Prevention of vascular graft occlusion and thrombus-associated thrombin generation by inhibition of factor XI.
The protease thrombin is required for normal hemostasis and pathologic thrombogenesis. Since the mechanism of coagulation factor… (More)
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Highly Cited
1999
Highly Cited
1999
Thrombin activates factor XI on activated platelets in the absence of factor XII.
Thrombin can activate factor XI in the presence of dextran sulfate or sulfatides. However, a physiological cofactor for thrombin… (More)
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Highly Cited
1998
Highly Cited
1998
Enhancement of rabbit jugular vein thrombolysis by neutralization of factor XI. In vivo evidence for a role of factor XI as an anti-fibrinolytic factor.
Recent in vitro studies have shown that fibrinolytic activity may be attenuated by a thrombin-activatable fibrinolysis inhibitor… (More)
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Highly Cited
1997
Highly Cited
1997
Thrombin-mediated activation of factor XI results in a thrombin-activatable fibrinolysis inhibitor-dependent inhibition of fibrinolysis.
Recently, it has been shown that Factor XI can be activated by thrombin, and that Factor XIa significantly contributes to the… (More)
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Highly Cited
1991
Highly Cited
1991
Factor XI activation in a revised model of blood coagulation.
Coagulation factor XI is activated in vitro by factor XIIa in the presence of high molecular weight kininogen (HMWK) and a… (More)
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Highly Cited
1991
Highly Cited
1991
Activation of human blood coagulation factor XI independent of factor XII. Factor XI is activated by thrombin and factor XIa in the presence of negatively charged surfaces.
Human blood coagulation factor XI was activated by either autoactivation or thrombin. These reactions occurred only in the… (More)
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Highly Cited
1977
Highly Cited
1977
Association of factor XI and high molecular weight kininogen in human plasma.
Factor XI and high molecular weight kininogen were found associated in normal human plasma at mol wt 380,000 as assessed by gel… (More)
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Highly Cited
1977
Highly Cited
1977
Human blood coagulation factor XI. Purification, properties, and mechanism of activation by activated factor XII.
Human blood coagulation Factor XI was purified in 20% yield from plasma by ion exchange chromatography. The specific clotting… (More)
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