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FZD1 protein, human

Known as: FzE1, Frizzled-1, hFz1 
Frizzled-1 (647 aa, ~71 kDa) is encoded by the human FZD1 gene. This protein is involved in the regulation of Wnt protein signaling.
National Institutes of Health

Related topics

Related topics

20 relations
Beta-Catenin Accumulation PathwayFZD1 geneFrizzled DomainG Protein-Coupled Receptor Genes

Broader (1)

Frizzled Receptors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes
The closure of an open anatomical structure by the directed growth and fusion of two tissue masses is a recurrent theme in… 
2009
2009
Dishevelled-2 docks and activates Src in a Wnt-dependent manner
Wnt3a activates the `canonical' signaling pathway, stimulating the nuclear accumulation of β-catenin and activation of Lef/Tcf… 
Highly Cited
2009
Highly Cited
2009
Effect of poloxamer 188 on lymphatic uptake of carvedilol-loaded solid lipid nanoparticles for bioavailability enhancement
The present work aimed to investigate the effect of different concentrations of poloxamer 188, a surfactant, on lymphatic uptake… 
Highly Cited
2004
Highly Cited
2004
Expression of Wnt genes and frizzled 1 and 2 receptors in normal breast epithelium and infiltrating breast carcinoma.
The Wnt genes encode a family of related, secreted proteins which initiate a signal cascade upon binding to cell surface receptor… 
Highly Cited
2004
Highly Cited
2004
The Low Density Lipoprotein Receptor-1, LRP1, Interacts with the Human Frizzled-1 (HFz1) and Down-regulates the Canonical Wnt Signaling Pathway*
Members of the low density lipoprotein receptor family (LDLR), LRP5/6, were shown to interact with the Frizzled (Fz) receptors… 
Highly Cited
2004
Highly Cited
2004
Identification of Domain Structures in the Propeptide of Corin Essential for the Processing of Proatrial Natriuretic Peptide*
Corin is a type II transmembrane serine protease and functions as the proatrial natriuretic peptide (pro-ANP) convertase in the… 
Highly Cited
2001
Highly Cited
2001
G Protein Signaling from Activated Rat Frizzled-1 to the β-Catenin-Lef-Tcf Pathway
The frizzled receptors, which mediate development and display seven hydrophobic, membrane-spanning segments, are cell membrane… 
Highly Cited
1999
Highly Cited
1999
Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response
The human homologue of fz1 (Hfz1) was cloned from a cDNA library. Hfz1 was shown to couple to Wnt signal transduction pathways by… 
Highly Cited
1996
Highly Cited
1996
A frizzled homolog functions in a vertebrate Wnt signaling pathway
Highly Cited
1992
Highly Cited
1992
Two homologs of the Drosophila polarity gene frizzled (fz) are widely expressed in mammalian tissues.
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