Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response

Abstract

The human homologue of fz1 (Hfz1) was cloned from a cDNA library. Hfz1 was shown to couple to Wnt signal transduction pathways by its ability to enhance Wnt induced TCF dependent transcription in both autocrine and paracrine modes. Enhanced TCF dependent signaling was dose dependent with respect to both Wnt-3A and Hfz1. Moreover, Hfz1 deletion mutants with… (More)
DOI: 10.1038/sj.onc.1202985

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