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FPR1 gene

Known as: FPR1, FMLP RECEPTOR, FORMYL PEPTIDE RECEPTOR 1 
This gene plays a role in G protein-coupled receptor signal transduction and chemotaxis.
National Institutes of Health

Related topics

Related topics

9 relations
ChemotaxisFPR1 protein, humanG Protein-Coupled Receptor SignalingLigand Binding

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FPR1 wt Allele

Papers overview

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Highly Cited
1998
Highly Cited
1998
Monocytes from Wiskott-Aldrich patients display reduced chemotaxis and lack of cell polarization in response to monocyte chemoattractant protein-1 and formyl-methionyl-leucyl-phenylalanine.
Wiskott-Aldrich syndrome (WAS) is an X-linked disorder characterized by trombocytopenia, eczema, and progressive decline of the… 
Highly Cited
1997
Highly Cited
1997
Borrelia burgdorferi outer surface protein A (OspA) activates and primes human neutrophils.
Lyme disease is caused by infection with the spirochete Borrelia burgdorferi and is characterized by bacterial persistence and… 
Highly Cited
1993
Highly Cited
1993
Effect of heparin, dermatan sulfate, and related oligo-derivatives on human polymorphonuclear leukocyte functions.
The in vitro effect of unfractionated heparin and dermatan sulfate, as well as oligo-heparin and oligo-dermatan sulfate, on human… 
Highly Cited
1991
Highly Cited
1991
Phospholipase D activation by platelet-activating factor, leukotriene B4, and formyl-methionyl-leucyl-phenylalanine in rabbit neutrophils. Phospholipase D activation is involved in enzyme release.
Lipid chemoattractants, such as platelet-activating factor and leukotriene B4, as well as the peptide chemoattractant FMLP, were… 
Highly Cited
1990
Highly Cited
1990
Phosphatidic acid and not diacylglycerol generated by phospholipase D is functionally linked to the activation of the NADPH oxidase by FMLP in human neutrophils.
Highly Cited
1986
Highly Cited
1986
Regulation of human neutrophil chemotaxis by intracellular pH.
The relationship of N-formyl-methionyl-leucyl-phenylalanine-stimulated Na+/H+ exchange to the chemotactic responsiveness of human… 
Highly Cited
1986
Highly Cited
1986
Tissue-specific phosphorylation of complement receptors CR1 and CR2
CR1 of neutrophils and monocytes may exist in a resting state, in which it only binds ligand-coated particles, or an activated… 
Highly Cited
1984
Highly Cited
1984
Chemotactic peptide-induced changes in neutrophil actin conformation
The effect of the chemotatic peptide, N- formylmethionylleucylphenylalanine (FMLP), on actin conformation in human neutrophils… 
Highly Cited
1983
Highly Cited
1983
Release of leukotriene B4 from human neutrophils and its relationship to degranulation induced by N-formyl-methionyl-leucyl-phenylalanine, serum-treated zymosan and the ionophore A23187.
The release of leukotriene B4 (LTB4) from human neutrophils and its relationship to degranulation induced by the divalent cation… 
Highly Cited
1979
Highly Cited
1979
Effects of a chemotactic factor, N-formylmethionyl peptide, on adherence, superoxide anion generation, phagocytosis, and microtubule assembly of human polymorphonuclear leukocytes.
FMLP promoted microtubule assembly in PMNs at concentrations which were chemotactic for the cells. At higher concentrations than… 
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