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Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals.
It is established that CFU-ECs are not EPCs and the role of these cells in angiogenesis must be re-examined prior to further clinical trials, whereas ECFCs may serve as a potential therapy for vascular regeneration. Expand
Identification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood.
These studies describe a clonogenic method to define a hierarchy of EPCs based on their proliferative potential, and they identify a unique population of high proliferation potential-endothelial colony-forming cells (HPP-ECFCs) in human umbilical cord blood. Expand
Assessing identity, phenotype, and fate of endothelial progenitor cells.
Some evidence is presented to consider emergence of a new paradigm for the process of neovascularization in the form of postnatal vasculogenesis and the role of endothelial progenitor cells in disease pathogenesis. Expand
CD41 expression defines the onset of primitive and definitive hematopoiesis in the murine embryo
CD41 expression marks the onset of primitive and definitive hematopoiesis in the murine embryo and persists as a marker of some stem and progenitor cell populations in the fetal liver and adult marrow, suggesting novel roles for this integrin. Expand
Human CD34+AC133+VEGFR-2+ cells are not endothelial progenitor cells but distinct, primitive hematopoietic progenitors.
It is found that CD34+AC133+VEGFR-2+ cells are HPCs that do not yield EC progeny, and the biological mechanism for their correlation with cardiovascular disease needs to be reexamined. Expand
BMP10 is essential for maintaining cardiac growth during murine cardiogenesis
An important pathway that involves a genetic interaction between BMP10, cell cycle regulatory proteins and several major cardiac transcription factors in orchestrating this transition in cardiogenesis at mid-gestation may provide an underlying mechanism for understanding the pathogenesis of both structural and functional congenital heart defects. Expand
Human endothelial progenitor cells.
  • M. Yoder
  • Biology, Medicine
  • Cold Spring Harbor perspectives in medicine
  • 1 July 2012
It is now clear that a host of hematopoietic and vascular endothelial subsets display the same panel of antigens and can only be discriminated by an extensive gene expression analysis or use of a variety of functional assays that are not often applied. Expand
Vessel wall-derived endothelial cells rapidly proliferate because they contain a complete hierarchy of endothelial progenitor cells.
It is demonstrated that a complete hierarchy of EPCs can be identified in HUVECs and HAECs derived from vessel walls and discriminated by their clonogenic and proliferative potential. Expand
Unresolved questions, changing definitions, and novel paradigms for defining endothelial progenitor cells.
A novel paradigm using proliferative potential as one defining aspect of E PC biology suggests that a hierarchy of EPCs exists in human blood and blood vessels. Expand
Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor Klf4.
The negative role of SOCS-3 on LIF signaling is verified and a novel role for Klf4 in ES cell function is provided, consistent with the notion that Klf 4 promotes ES cell self-renewal. Expand