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FLNC protein, human

Known as: FLN2 protein, human, filamin 2, ABP-L 
Filamin-C (2725 aa, ~291 kDa) is encoded by the human FLNC gene. This protein plays a role in the organization of the cytoskeleton of muscle fibers.
National Institutes of Health

Related topics

Related topics

9 relations
Actin-Binding ProteinCytoskeletonFLNC geneMyofibrillar Myopathy

Broader (2)

Filamin CFilamins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2020
Review
2020
Structure and Function of Filamin C in the Muscle Z-Disc
Filamin C (FLNC) is one of three filamin proteins (Filamin A (FLNA), Filamin B (FLNB), and FLNC) that cross-link actin filaments… 
Highly Cited
2016
Highly Cited
2016
HSPB7 interacts with dimerized FLNC and its absence results in progressive myopathy in skeletal muscles
ABSTRACT HSPB7 belongs to the small heat-shock protein (sHSP) family, and its expression is restricted to cardiac and skeletal… 
Highly Cited
2007
Highly Cited
2007
Loss of muscle-specific RING-finger 3 predisposes the heart to cardiac rupture after myocardial infarction
RING-finger proteins commonly function as ubiquitin ligases that mediate protein degradation by the ubiquitin-proteasome pathway… 
Highly Cited
2004
Highly Cited
2004
Evidence for a dominant-negative effect in ACTA1 nemaline myopathy caused by abnormal folding, aggregation and altered polymerization of mutant actin isoforms.
We have studied a cohort of nemaline myopathy (NM) patients with mutations in the muscle alpha-skeletal actin gene (ACTA1… 
Highly Cited
2002
Highly Cited
2002
Calsarcin-3, a Novel Skeletal Muscle-specific Member of the Calsarcin Family, Interacts with Multiple Z-disc Proteins*
The Z-disc is a highly specialized multiprotein complex of striated muscles that serves as the interface of the sarcomere and the… 
Highly Cited
2002
Highly Cited
2002
myotilin Mutation found in second pedigree with LGMD1A.
Limb-girdle muscular dystrophy 1A (LGMD1A [MIM 159000]) is an autosomal dominant form of muscular dystrophy characterized by… 
Review
2001
Review
2001
Telethonin and Other New Proteins of the Z‐Disc of Skeletal Muscle
This brief review outlines some of the most relevant proteins of the Z‐disc and the complex network of interactions that link… 
Highly Cited
2000
Highly Cited
2000
FATZ, a Filamin-, Actinin-, and Telethonin-binding Protein of the Z-disc of Skeletal Muscle*
We report the identification and characterization of a novel 32-kDa protein expressed in skeletal muscle and located in the Z… 
Highly Cited
2000
Highly Cited
2000
Indications for a Novel Muscular Dystrophy Pathway
γ-Filamin, also called ABP-L, is a filamin isoform that is specifically expressed in striated muscles, where it is predominantly… 
Highly Cited
2000
Highly Cited
2000
Characterization of muscle filamin isoforms suggests a possible role of gamma-filamin/ABP-L in sarcomeric Z-disc formation.
Filamin, also called actin binding protein-280, is a dimeric protein that cross-links actin filaments in the cortical cytoplasm… 
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