Skip to search formSkip to main contentSkip to account menu

FHIT wt Allele

Known as: FRA3B, Fragile Histidine Triad wt Allele 
Human FHIT wild-type allele is located in the vicinity of 3p14.2 and is approximately 1499 kb in length. This allele, which encodes bis(5'-adenosyl… 
National Institutes of Health

Related topics

Related topics

7 relations
3p14.2Cervix carcinomaFHIT Gene InactivationHomo sapiens

Broader (1)

FHIT gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
ATR preferentially interacts with common fragile site FRA3B and the binding requires its kinase activity in response to aphidicolin treatment.
2005
2005
Expression of common chromosomal fragile site genes, WWOX/FRA16D and FHIT/FRA3B is downregulated by exposure to environmental carcinogens, UV, and BPDE but not by IR
Common chromosomal fragile sites are unstable genomic loci susceptible to breakage, rearrangement, and are highly recombinogenic… 
1998
1998
Frequent homozygous deletions in the FRA3B region in tumor cell lines still leave the FHIT exons intact
FRA3B at human chromosomal band 3p14.2 is the most active common fragile site in the human genome. The molecular mechanism of… 
1998
1998
Tumor suppressor genes: does FHIT fit?
What is a tumor suppressor gene? From a functional point of view, it is a gene whose product can restrict the tumorigenic and… 
1997
1997
FHIT gene and the FRA3B region are not involved in the genetics of renal cell carcinomas
The FHIT gene locus at 3p14.2 covers about 500 kb, including the fragile site FRA3B and the constitutional t(3;8) breakpoint… 
1997
1997
Normal FHIT transcripts in renal cell cancer‐ and lung cancer‐derived cell lines, including a cell line with a homozygous deletion in the FRA3B region
The recently identified FHIT gene encompasses the FRA3B region and the breakpoint of a constitutive t(3;8) occurring in a family… 
Highly Cited
1997
Highly Cited
1997
Aphidicolin-induced FRA3B breakpoints cluster in two distinct regions.
The common fragile site at chromosomal band 3p14.2 (FRA3B) is the most sensitive single site in the human genome to induced… 
Highly Cited
1996
Highly Cited
1996
A 350-kb cosmid contig in 3p14.2 that crosses the t(3;8) hereditary renal cell carcinoma translocation breakpoint and 17 aphidicolin-induced FRA3B breakpoints.
The constitutive fragile site at human chromosomal band 3p14.2, FRA3B, has been described as the most active common fragile site… 
1995
1995
Precise localization of aphidicolin-induced breakpoints on the short arm of human chromosome 3.
The common fragile site at 3p14.2 (FRA3B) has been described as the most active fragile site in the human genome. This locus may… 
1988
1988
Translocation t(3;8)(p14.2;q24.1) in renal cell carcinoma affects expression of the common fragile site at 3p14(FRA3B) in lymphocytes.
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)