FHIT gene

Known as: FHIT, AP3A HYDROLASE, Fragile Histidine Triad Gene 
This gene is involved in nucleotide metabolism and cell cycle control.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1988-2018
020406019882018

Papers overview

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Highly Cited
2001
Highly Cited
2001
Allele loss and loss of expression of fragile histidine triad (FHIT), a putative tumor suppressor gene located in chromosome… (More)
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Highly Cited
1999
Highly Cited
1999
Alteration of the FHIT (fragile histidine triad) gene occurs as an early and frequent event in lung carcinogenesis. FHIT gene… (More)
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Highly Cited
1999
Highly Cited
1999
We studied the effects of fragile histidine triad (FHIT) gene overexpression mediated by an adenoviral vector, Ad-FHIT, on cell… (More)
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Highly Cited
1998
Highly Cited
1998
We previously cloned and characterized the tumor suppressor gene FHIT (fragile histidine triad) at chromosome 3p14.2 and found… (More)
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Highly Cited
1997
Highly Cited
1997
The candidate tumor suppressor gene, FHIT, encompasses the common human chromosomal fragile site at 3p14.2, the hereditary renal… (More)
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Highly Cited
1997
Highly Cited
1997
Epidemiologic data have strongly indicated that cigarette smoking is linked to the development of lung cancer. However, little is… (More)
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Highly Cited
1997
Highly Cited
1997
The FHIT gene, encoded by 10 exons in a 1.1-kb transcript, encompasses approximately 1 Mb of genomic DNA, which includes the… (More)
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Highly Cited
1996
Highly Cited
1996
A 200-300 kb region of chromosome 3p14.2, including the fragile site locus FRA3B, is homozygously deleted in multiple tumor… (More)
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Highly Cited
1996
Highly Cited
1996
Chromosome 3p deletions in breast cancer have been detected at 3p12-p21 by cytogenetic and loss of heterozygosity studies… (More)
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Highly Cited
1996
Highly Cited
1996
To determine whether the FHIT gene at 3p14.2 is altered in head and neck squamous cell carcinomas (HNSCC), we examined 26 HNSCC… (More)
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