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High-resolution DNA copy number and gene expression analyses distinguish chromophobe renal cell carcinomas and renal oncocytomas
BackgroundThe diagnosis of benign renal oncocytomas (RO) and chromophobe renal cell carcinomas (RCC) based on their morphology remains uncertain in several cases.MethodsWe have applied AffymetrixExpand
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Clonal chromosome abnormalities in tumor cells from patients with sporadic renal cell carcinomas.
The karyotype of 75 sporadic, nonpapillary renal cell carcinomas was analyzed using chromosome banding techniques. Sixty-five tumors had near-diploid stemlines, and ten had near-triploid orExpand
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Specific chromosome aberration in human renal cell carcinoma
Using G‐banding technique, the chromosomes were studied in short‐term cultures of 25 primary renal‐cell carcinomas (RCC). Phytohaemagglutinin‐stimulated peripheral blood lymphocytes or normal kidneyExpand
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Specific loss of chromosomes 1, 2, 6, 10, 13, 17, and 21 in chromophobe renal cell carcinomas revealed by comparative genomic hybridization.
We analyzed 19 chromophobe renal cell carcinomas by means of comparative genomic hybridization. Two tumors revealed no numerical abnormalities. In the remaining 17 cases we found loss of entireExpand
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Characterization of a continuous cell line (MHH-NB-11) derived from advanced neuroblastoma.
A continuous cell line was established from an explanted tumor biopsy obtained from a patient with advanced neuroblastoma, which showed no response to chemotherapy. This cell line MHH-NB-11 retainedExpand
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Detection of complete and partial chromosome gains and losses by comparative genomic in situ hybridization
Comparative genomic in situ hybridization (CGH) provides a new possibility for searching genomes for imbalanced genetic material. Labeled genomic test DNA, prepared from clinical or tumor specimens,Expand
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Oncocytoid renal cell carcinoma after neuroblastoma: a report of four cases of a distinct clinicopathologic entity.
Four children who developed oncocytoid renal cell carcinoma (RCC) after neuroblastoma are reported. One patient had multiple, bilateral RCCs. The mean age at time of diagnosis of RCC was 8.8 yearsExpand
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Molecular differential diagnosis of renal cell carcinomas by microsatellite analysis.
Recent application of molecular cytogenetic techniques has resulted in a new type of genetic classification of renal cell tumors. The key aspect of the novel diagnostic concept is reflected byExpand
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Inflammatory protein serum amyloid A1 marks a subset of conventional renal cell carcinomas with fatal outcome.
BACKGROUND Conventional renal cell carcinoma (RCC) is the most common renal cancer. As the metastatic conventional RCC is practically incurable, there is a need for markers to estimate the tumourExpand
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Tissue‐specific expression of a constitutional 3;6 translocation: Development of multiple bilateral renal‐cell carcinomas
We describe a German family carrying a constitutional translocation (3;6) (p13;q25.1) in 3 consecutive generations. The only member of the family over 50 years of age and carrying the translocationExpand
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