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FHIT protein, human

Known as: Fragile Histidine Triad Protein, Bis(5'-Adenosyl)-Triphosphatase, FHIT 
Bis(5'-adenosyl)-triphosphatase (147 aa, ~17 kDa) is encoded by the human FHIT gene. This protein is involved in nucleoside metabolism.
National Institutes of Health

Related topics

Related topics

6 relations
Enzyme GeneFHIT geneHydrolysisNucleotide Metabolism

Narrower (1)

bis(5'-adenosyl)-triphosphatase

Broader (1)

fragile histidine triad protein

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Hypermethylation and loss of heterozygosity of tumor suppressor genes on chromosome 3p in cervical cancer.
Review
2007
Review
2007
Non-random inactivation of large common fragile site genes in different cancers
The common fragile sites are regions of profound genomic instability found in all individuals. The full size of each region of… 
Highly Cited
2005
Highly Cited
2005
Promoter hypermethylation of p16INK4a, E-cadherin, O6-MGMT, DAPK and FHIT in adenocarcinomas of the esophagus, esophagogastric junction and proximal stomach.
Although the incidence of Barrett's carcinomas (BC) and proximal gastric adenocarcinomas (PGC) is increasing, little is known… 
Highly Cited
2002
Highly Cited
2002
Adenosine Monophosphoramidase Activity of Hint and Hnt1 Supports Function of Kin28, Ccl1, and Tfb3* 210
The histidine triad superfamily of nucleotide hydrolases and nucleotide transferases consists of a branch of proteins related to… 
Highly Cited
2001
Highly Cited
2001
Effect of adenoviral transduction of the fragile histidine triad gene into esophageal cancer cells.
Reintroduction of a tumor suppressor gene product in cancer cells is a promising strategy for cancer gene therapy. The fragile… 
Highly Cited
2001
Highly Cited
2001
Loss of Fhit expression is a predictor of poor outcome in tongue cancer.
Abnormalities of FHIT, a candidate tumor suppressor gene located at 3pl4.2, have been found frequently in multiple tumor types… 
Highly Cited
2000
Highly Cited
2000
The expression of Fhit protein is related inversely to disease progression in patients with breast carcinoma
The FHIT gene, located at human chromosome 3p14.2, frequently is deleted in a number of human tumors, including breast carcinoma… 
Highly Cited
1999
Highly Cited
1999
FHIT loss of function in human primary breast cancer correlates with advanced stage of the disease.
The FHIT gene, encompassing the FRA3B fragile site at chromosome 3p14.2, is a tumor suppressor gene involved in different tumor… 
Highly Cited
1999
Highly Cited
1999
The FHIT gene is expressed in pancreatic ductular cells and is altered in pancreatic cancers.
We examined 2 normal pancreata, 21 primary pancreatic ductal cancers, and 19 pancreatic cancer cell lines for Fhit expression and… 
Highly Cited
1996
Highly Cited
1996
Molecular analysis of the FHIT gene at 3p14.2 in lung cancer cell lines.
Chromosome 3p is frequently deleted in various cancers including examples in the lung. A novel gene, termed FHIT, was recently… 
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