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FHIT protein, human

Known as: Fragile Histidine Triad Protein, Bis(5'-Adenosyl)-Triphosphatase, FHIT 
Bis(5'-adenosyl)-triphosphatase (147 aa, ~17 kDa) is encoded by the human FHIT gene. This protein is involved in nucleoside metabolism.
National Institutes of Health

Papers overview

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Highly Cited
2005
Highly Cited
2005
This study aimed to (a) determine if DNA methylation is a mechanism of WWOX (WW domain containing oxidoreductase) and FHIT… Expand
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Highly Cited
2004
Highly Cited
2004
BACKGROUND FHIT and WWOX are a tumor suppressor and a candidate suppressor that encompass the FRA3B and FRA16D fragile sites at… Expand
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Highly Cited
2003
Highly Cited
2003
Promoter hypermethylation is an alternative way to inactivate tumor suppressor genes in cancer. Alterations of chromosome 3p are… Expand
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Highly Cited
2001
Highly Cited
2001
Allele loss and loss of expression of fragile histidine triad (FHIT), a putative tumor suppressor gene located in chromosome… Expand
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Highly Cited
2001
Highly Cited
2001
The tumor suppressor gene FHIT spans a common fragile site and is highly susceptible to environmental carcinogens. FHIT… Expand
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Highly Cited
1999
Highly Cited
1999
ABSTRACT: Through investigation of hemizygous and homozygous deletions in common human cancers, including lung cancer, we have… Expand
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Highly Cited
1998
Highly Cited
1998
We previously cloned and characterized the tumor suppressor gene FHIT (fragile histidine triad) at chromosome 3p14.2 and found… Expand
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Highly Cited
1997
Highly Cited
1997
The candidate tumor suppressor gene, FHIT, encompasses the common human chromosomal fragile site at 3p14.2, the hereditary renal… Expand
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Highly Cited
1996
Highly Cited
1996
Human Fhit (fragile histidine triad) protein, encoded by the FHIT putative tumor suppressor gene, is a typical dinucleoside 5',5… Expand
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Highly Cited
1996
Highly Cited
1996
Chromosome 3p deletions in breast cancer have been detected at 3p12-p21 by cytogenetic and loss of heterozygosity studies… Expand
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