Effect of adenoviral transduction of the fragile histidine triad gene into esophageal cancer cells.

@article{Ishii2001EffectOA,
  title={Effect of adenoviral transduction of the fragile histidine triad gene into esophageal cancer cells.},
  author={Hideshi Ishii and Kristoffel R. Dumon and Andrea Vecchione and Francesco Trapasso and Koshi Mimori and Hansjuerg Alder and Masaki Mori and Gabriella Sozzi and Raffaele Baffa and Kay F Huebner and Carlo M. Croce},
  journal={Cancer research},
  year={2001},
  volume={61 4},
  pages={1578-84}
}
Reintroduction of a tumor suppressor gene product in cancer cells is a promising strategy for cancer gene therapy. The fragile histidine triad (FHIT) gene has been identified in a region at chromosome 3p14.2, which is deleted in many tumors, including esophageal cancer. Previous studies have shown frequent biallelic alterations of the FHIT gene in numerous tumors, and have demonstrated a tumor suppressor function of Fhit. We have studied the biological effects of adenoviral-FHIT transduction in… CONTINUE READING
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