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FEN1 gene

Known as: Flap Structure-Specific Endonuclease 1 Gene, MATURATION FACTOR 1, FLAP STRUCTURE-SPECIFIC ENDONUCLEASE 1 
This gene is involved in DNA replication and repair.
National Institutes of Health

Related topics

Related topics

6 relations
Base Excision RepairDNA ReplicationDouble Strand Break RepairFlap Endonuclease-1

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Comparative genomic analysis of duplicated homoeologous regions involved in the resistance of Brassica napus to stem canker
All crop species are current or ancient polyploids. Following whole genome duplication, structural and functional modifications… 
2012
2012
Identification of Proteins Sensitive to Thermal Stress in Human Neuroblastoma and Glioma Cell Lines
Heat-shock is an acute insult to the mammalian proteome. The sudden elevation in temperature has far-reaching effects on protein… 
2009
2009
Amino acid Asp181 of 5'-flap endonuclease 1 is a useful target for chemotherapeutic development.
DNA alkylation-induced damage is one of the most efficacious anticancer therapeutic strategies. Enhanced DNA alkylation and… 
2008
2008
Dynamic Removal of Replication Protein A by Dna2 Facilitates Primer Cleavage during Okazaki Fragment Processing in Saccharomyces cerevisiae*
Eukaryotic Okazaki fragments are initiated by a RNA/DNA primer, which is removed before the fragments are joined. Polymerase… 
2006
2006
Flap Endonuclease Disengages Dna2 Helicase/Nuclease from Okazaki Fragment Flaps*
Okazaki fragments contain an initiator RNA/DNA primer that must be removed before the fragments are joined. In eukaryotes, the… 
2004
2004
The Fen1 extrahelical 3'-flap pocket is conserved from archaea to human and regulates DNA substrate specificity.
Fen1 is a key enzyme for the maintenance of genetic stability in archaea and eukaryotes and is classified as a tumor suppressor… 
2001
2001
The ‘flap’ endonuclease gene FEN1 is excluded as a candidate gene implicated in the CAG repeat expansion underlying Huntington disease
At least 12 disorders including Huntington disease (HD) are associated with expansion of a trinucleotide repeat (TNR). Factors… 
2000
2000
Genetic variability in milking speed of dairy goats.
The present investigation deals with the genetic variability of milking speed, measured as the volume of milk collected during… 
1998
1998
Fen1 expression: a novel marker for cell proliferation
The identification of antigens whose expression is associated with the cell cycle is a particularly attractive method with which… 
1991
1991
Comparative Mg(2+)-dependent sequential covalent binding stoichiometries of 3'-O-(4-benzoyl)benzoyl adenosine 5'-diphosphate of MF1, TF1, and the alpha 3 beta 3 core complex of TF1. The binding…
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