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Prohibitins act as a membrane‐bound chaperone for the stabilization of mitochondrial proteins
Prohibitins are ubiquitous, abundant and evolutionarily strongly conserved proteins that play a role in important cellular processes. Using blue native electrophoresis we have demonstrated that humanExpand
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Regulation of cell number in the mammalian gastrointestinal tract: the importance of apoptosis.
The regulation of cell number in adult tissues is determined by the balance of cell production and cell loss. In the gastrointestinal tract, where there are well defined zones of proliferation andExpand
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The prohibitin family of mitochondrial proteins regulate replicative lifespan
Cellular senescence is determined by multiple factors, including the genetic regulation of metabolism and responses to endogenous and exogenous stresses [1-4]. Recent studies implicate a limitedExpand
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The mitochondrial PHB complex: roles in mitochondrial respiratory complex assembly, ageing and degenerative disease
Abstract. Although originally identified as putative negative regulators of the cell cycle, recent studies have demonstrated that the PHB proteins act as a chaperone in the assembly of subunits ofExpand
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In situ end‐labelling detects DNA strand breaks in apoptosis and other physiological and pathological states
We have investigated the use of a novel technique, in situ end‐labelling, as a means of the specific identification of apoptotic cells in formalin‐fixed, paraffin‐processed tissue sections. TheExpand
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Sensitive detection of Helicobacter pylori by using polymerase chain reaction.
A polymerase chain reaction (PCR) for the specific detection of Helicobacter pylori was developed with a single primer pair derived from the nucleotide sequence of the urease A gene of H. pylori. WeExpand
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Discriminating functional and non‐functional p53 in human tumours by p53 and MDM2 immunohistochemistry
Mutation and/or loss of the TP53 tumour suppressor gene is the single most common genetic abnormality in human cancer. The majority of TP53 mutations lead to stabilization of the protein, so thatExpand
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Differential expression of p63 isoforms in normal tissues and neoplastic cells
The p63 gene encodes at least six different proteins with homology to the tumour suppressor protein p53 and the related p53 family member p73. So far, there have been limited data concerning theExpand
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C-terminal phosphorylation of Hsp70 and Hsp90 regulates alternate binding to co-chaperones CHIP and HOP to determine cellular protein folding/degradation balances
Heat shock proteins Hsp90 and Hsp70 facilitate protein folding but can also direct proteins for ubiquitin-mediated degradation. The mechanisms regulating these opposite activities involve Hsp bindingExpand
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Radiation-induced genomic instability and bystander effects: inter-related nontargeted effects of exposure to ionizing radiation
The paradigm of genetic alterations being restricted to direct DNA damage after exposure to ionizing radiation has been challenged by observations in which cells that are not exposed to ionizingExpand
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