Flap Endonuclease-1

Known as: RAD2 Homolog-1 Nuclease, DNase IV, Fen1 Protein 
Flap endonuclease 1 (380 aa, ~43 kDa) is encoded by the human FEN1 gene. This protein is involved in both the removal of 5' overhangs during DNA… (More)
National Institutes of Health

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Highly Cited
2008
Highly Cited
2008
Telomere stability plays an important role in the preservation of genomic stability and is maintained through the coordinated… (More)
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Highly Cited
2005
Highly Cited
2005
Flap endonuclease-1 (FEN1) is a key enzyme for maintaining genomic stability and replication. Proliferating cell nuclear antigen… (More)
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Review
2004
Review
2004
One strand of cellular DNA is generated as RNA-initiated discontinuous segments called Okazaki fragments that later are joined… (More)
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Highly Cited
2004
Highly Cited
2004
Human Proliferating Cellular Nuclear Antigen (hPCNA), a member of the sliding clamp family of proteins, makes specific protein… (More)
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Highly Cited
2001
Highly Cited
2001
Werner syndrome (WS) is a human premature aging disorder characterized by chromosomal instability. The cellular defects of WS… (More)
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Highly Cited
2000
Highly Cited
2000
Human flap endonuclease 1 (FEN1), an essential DNA replication protein, cleaves substrates with unannealed 5'-tails. FEN1… (More)
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1998
1998
Flap endonuclease-1 (FEN-1), a structure specific nuclease, is an essential enzyme for eukaryotic DNA replication and repair. The… (More)
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Highly Cited
1998
Highly Cited
1998
Flap endonuclease (FEN-1) removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging… (More)
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Highly Cited
1998
Highly Cited
1998
Base excision repair can proceed in either one of two alternative pathways: a DNA polymerase beta-dependent pathway and a… (More)
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Highly Cited
1994
Highly Cited
1994
The repair of some types of DNA double-strand breaks is thought to proceed through DNA flap structure intermediates. A DNA flap… (More)
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