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FBXW7 protein, human

Known as: Archipelago Homolog, Archipelago Homolog Protein, SEL-10 protein, human 
F-box/WD repeat-containing protein 7 (707 aa, ~80 kDa) is encoded by the human FBXW7 gene. This protein plays a role in the regulation of protein… 
National Institutes of Health

Related topics

Related topics

11 relations
Binding ProteinsF-Box DomainFBXW7 geneGenes, Regulator

Broader (3)

Cell Cycle ProteinsF-Box Proteinsubiquitin-protein ligase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
miR-23a promotes the transition from indolent to invasive colorectal cancer.
Colorectal cancer is a classic example of a tumor that progresses through multiple distinct stages in its evolution. To… 
Highly Cited
2010
Highly Cited
2010
NOTCH1 and/or FBXW7 mutations predict for initial good prednisone response but not for improved outcome in pediatric T-cell acute lymphoblastic leukemia patients treated on DCOG or COALL protocols
Aberrant activation of the NOTCH1 pathway by inactivating and activating mutations in NOTCH1 or FBXW7 is a frequent phenomenon in… 
Highly Cited
2010
Highly Cited
2010
The favorable effect of activating NOTCH1 receptor mutations on long-term outcome in T-ALL patients treated on the ALL–BFM 2000 protocol can be separated from FBXW7 loss of function
Precursor T-cell acute lymphoblastic leukemia (T-ALL) remains an important challenge in pediatric oncology. Because of the… 
Highly Cited
2009
Highly Cited
2009
NOTCH1/FBXW7 mutation identifies a large subgroup with favorable outcome in adult T-cell acute lymphoblastic leukemia (T-ALL): a Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL…
Many somatic genetic abnormalities have been identified in T-cell acute lymphoblastic leukemia (T-ALL) but each individual… 
Highly Cited
2009
Highly Cited
2009
FBXW7 and NOTCH1 mutations in childhood T cell acute lymphoblastic leukaemia and T cell non‐Hodgkin lymphoma
Mutation analysis of FBXW7 and NOTCH1 genes was performed in 55 T cell acute lymphoblastic leukaemia (T‐ALL) and 14 T cell non… 
Highly Cited
2003
Highly Cited
2003
BRAF and FBXW7 (CDC4, FBW7, AGO, SEL10) mutations in distinct subsets of pancreatic cancer: potential therapeutic targets.
Highly Cited
2002
Highly Cited
2002
hCDC4 gene mutations in endometrial cancer.
Cyclin-dependent kinase 2 activated by cyclin E is involved in the initiation of DNA replication and other S phase functions… 
Highly Cited
2001
Highly Cited
2001
Functional Interaction between SEL-10, an F-box Protein, and the Nuclear Form of Activated Notch1 Receptor*
The Notch signaling pathway is essential in many cell fate decisions in invertebrates as well as in vertebrates. After ligand… 
Highly Cited
2001
Highly Cited
2001
SEL-10 Is an Inhibitor of Notch Signaling That Targets Notch for Ubiquitin-Mediated Protein Degradation
ABSTRACT Notch receptors and their ligands play important roles in both normal animal development and pathogenesis. We show here… 
Highly Cited
1997
Highly Cited
1997
sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins.
Mutations that influence lin-12 activity in Caenorhabditis elegans may identify conserved factors that regulate the activity of… 
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