FBXW7 protein, human

Known as: Archipelago Homolog, Archipelago Homolog Protein, SEL-10 protein, human 
F-box/WD repeat-containing protein 7 (707 aa, ~80 kDa) is encoded by the human FBXW7 gene. This protein plays a role in the regulation of protein… (More)
National Institutes of Health

Papers overview

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Highly Cited
2018
Highly Cited
2018
Background Circular RNAs (circRNAs) are RNA transcripts that are widespread in the eukaryotic genome. Recent evidence indicates… (More)
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Highly Cited
2013
Highly Cited
2013
Sequencing efforts led to the identification of somatic mutations that could affect the self-renewal and differentiation of… (More)
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Highly Cited
2012
Highly Cited
2012
Background:F-box and WD repeat domain-containing 7 (FBXW7) is a cell cycle regulatory gene whose protein product ubiquitinates… (More)
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Highly Cited
2011
Highly Cited
2011
The Fbxw7 (F-box/WD repeat-containing protein 7; also called CDC4, Sel10, Ago, and Fbw7) component of the SCF (Skp1/Cullin/F-box… (More)
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Highly Cited
2010
Highly Cited
2010
Aberrant activation of the NOTCH1 pathway by inactivating and activating mutations in NOTCH1 or FBXW7 is a frequent phenomenon in… (More)
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2010
2010
Inflammation and hypoxia are known to promote the metastatic progression of tumours. The CCAAT/enhancer-binding protein-δ (C/EBP… (More)
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Highly Cited
2009
Highly Cited
2009
Many somatic genetic abnormalities have been identified in T-cell acute lymphoblastic leukemia (T-ALL) but each individual… (More)
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Highly Cited
2008
Highly Cited
2008
The enzyme mTOR (mammalian target of rapamycin) is a major target for therapeutic intervention to treat many human diseases… (More)
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Highly Cited
2007
Highly Cited
2007
The ubiquitin-proteasome system is a major regulatory pathway of protein degradation and plays an important role in cellular… (More)
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Highly Cited
2003
Highly Cited
2003
The recognition of biologically distinct tumor subsets is fundamental to understanding tumorigenesis. This study investigated the… (More)
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