ubiquitin-protein ligase

Known as: Ligases, Ubiquitin-Protein, Ligase, Ubiquitin-Protein, Ligase, E3 
E3 Ubiquitin Ligases are ATP-dependent enzymes that catalyze the formation of a covalent bond between ubiquitous intracellular Ubiquitin proteins and… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1989-2018
020040019892018

Papers overview

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Highly Cited
2010
Highly Cited
2010
Tumour-necrosis factor (TNF) receptor-associated factor 2 (TRAF2) is a key component in NF-kappaB signalling triggered by TNF… (More)
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Highly Cited
2008
Highly Cited
2008
BACKGROUND An important layer of active defense in plant immunity is the detection of pathogen-associated molecular patterns… (More)
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Highly Cited
2007
Highly Cited
2007
Skeletal muscle atrophy occurs as a side effect of treatment with synthetic glucocorticoids such as dexamethasone (DEX) and is a… (More)
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Highly Cited
2004
Highly Cited
2004
Transcription factor Nrf2 is a major regulator of genes encoding phase 2 detoxifying enzymes and antioxidant stress proteins in… (More)
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Highly Cited
2004
Highly Cited
2004
The Nrf2 transcription factor promotes survival following cellular insults that trigger oxidative damage. Nrf2 activity is… (More)
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Highly Cited
2002
Highly Cited
2002
The SCF ubiquitin E3 ligase regulates ubiquitin-dependent proteolysis of many regulatory proteins such as p27(Kip1), IkappaB, and… (More)
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Highly Cited
2001
Highly Cited
2001
Cyclin E binds and activates the cyclin-dependent kinase Cdk2 and catalyzes the transition from the G1 phase to the S phase of… (More)
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Highly Cited
2001
Highly Cited
2001
NEDD8/Rub1 is a ubiquitin (Ub)-like post-translational modifier that is covalently linked to cullin (Cul)-family proteins in a… (More)
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Highly Cited
2001
Highly Cited
2001
The ubiquitin-proteasome system catalyses the immediate destruction of misfolded or impaired proteins generated in cells, but how… (More)
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Highly Cited
1999
Highly Cited
1999
Mutations of von Hippel-Lindau disease (VHL) tumor-suppressor gene product (pVHL) are found in patients with dominant inherited… (More)
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