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ubiquitin-protein ligase

Known as: Ligases, Ubiquitin-Protein, Ligase, Ubiquitin-Protein, Ligase, E3 
E3 Ubiquitin Ligases are ATP-dependent enzymes that catalyze the formation of a covalent bond between ubiquitous intracellular Ubiquitin proteins and… 
National Institutes of Health

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BIRC2 protein, humanBIRC3 protein, humanBUL1 protein, S cerevisiaeCOP1 protein, Arabidopsis
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BIRC4 protein, humanEnzyme GeneIn BloodPARK2 gene
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Papers overview

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Highly Cited
2011
Highly Cited
2011
SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis
SHARPIN is a ubiquitin-binding and ubiquitin-like-domain-containing protein which, when mutated in mice, results in immune system… 
Review
2009
Review
2009
Physiological functions of the HECT family of ubiquitin ligases
The ubiquitylation of proteins is carried out by E1, E2 and E3 (ubiquitin ligase) enzymes, and targets them for degradation or… 
Highly Cited
2004
Highly Cited
2004
Keap1 Is a Redox-Regulated Substrate Adaptor Protein for a Cul3-Dependent Ubiquitin Ligase Complex
ABSTRACT The bZIP transcription factor Nrf2 controls a genetic program that protects cells from oxidative damage and maintains… 
Highly Cited
2004
Highly Cited
2004
Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase To Regulate Proteasomal Degradation of Nrf2
ABSTRACT Transcription factor Nrf2 is a major regulator of genes encoding phase 2 detoxifying enzymes and antioxidant stress… 
Highly Cited
2001
Highly Cited
2001
U Box Proteins as a New Family of Ubiquitin-Protein Ligases*
The U box is a domain of ∼70 amino acids that is present in proteins from yeast to humans. The prototype U box protein, yeast… 
Review
2001
Review
2001
Mechanisms underlying ubiquitination.
  • C. Pickart
  • Annual review of biochemistry
  • 2001
  • Corpus ID: 25577291
The conjugation of ubiquitin to other cellular proteins regulates a broad range of eukaryotic cell functions. The high efficiency… 
Highly Cited
2001
Highly Cited
2001
CHIP is a chaperone‐dependent E3 ligase that ubiquitylates unfolded protein
The ubiquitin–proteasome system catalyses the immediate destruction of misfolded or impaired proteins generated in cells, but how… 
Highly Cited
2000
Highly Cited
2000
Mdm2 Is a RING Finger-dependent Ubiquitin Protein Ligase for Itself and p53*
Mdm2 has been shown to regulate p53 stability by targeting the p53 protein for proteasomal degradation. We now report that Mdm2… 
Highly Cited
1999
Highly Cited
1999
The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase.
Ubiquitination of receptor protein-tyrosine kinases (RPTKs) terminates signaling by marking active receptors for degradation. c… 
Highly Cited
1995
Highly Cited
1995
A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase.
E6-AP is a 100-kDa cellular protein that interacts with the E6 protein of the cancer-associated human papillomavirus types 16 and… 
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