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ubiquitin-protein ligase
Known as:
Ligases, Ubiquitin-Protein
, Ligase, Ubiquitin-Protein
, Ligase, E3
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E3 Ubiquitin Ligases are ATP-dependent enzymes that catalyze the formation of a covalent bond between ubiquitous intracellular Ubiquitin proteins and…
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National Institutes of Health
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Related topics
Related topics
50 relations
Narrower (39)
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis
F. Ikeda
,
Yonathan Lissanu Deribe
,
+17 authors
I. Dikic
Nature
2011
Corpus ID: 4422738
SHARPIN is a ubiquitin-binding and ubiquitin-like-domain-containing protein which, when mutated in mice, results in immune system…
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Review
2009
Review
2009
Physiological functions of the HECT family of ubiquitin ligases
D. Rotin
,
Sharad Kumar
Nature Reviews Molecular Cell Biology
2009
Corpus ID: 1894155
The ubiquitylation of proteins is carried out by E1, E2 and E3 (ubiquitin ligase) enzymes, and targets them for degradation or…
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Highly Cited
2004
Highly Cited
2004
Keap1 Is a Redox-Regulated Substrate Adaptor Protein for a Cul3-Dependent Ubiquitin Ligase Complex
Donna D. Zhang
,
S. Lo
,
J. Cross
,
D. Templeton
,
M. Hannink
Molecular and Cellular Biology
2004
Corpus ID: 15603390
ABSTRACT The bZIP transcription factor Nrf2 controls a genetic program that protects cells from oxidative damage and maintains…
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Highly Cited
2004
Highly Cited
2004
Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase To Regulate Proteasomal Degradation of Nrf2
A. Kobayashi
,
Moon-Il Kang
,
+5 authors
Masayuki Yamamoto
Molecular and Cellular Biology
2004
Corpus ID: 43427532
ABSTRACT Transcription factor Nrf2 is a major regulator of genes encoding phase 2 detoxifying enzymes and antioxidant stress…
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Highly Cited
2001
Highly Cited
2001
U Box Proteins as a New Family of Ubiquitin-Protein Ligases*
S. Hatakeyama
,
M. Yada
,
M. Matsumoto
,
N. Ishida
,
K. Nakayama
The Journal of Biological Chemistry
2001
Corpus ID: 8967695
The U box is a domain of ∼70 amino acids that is present in proteins from yeast to humans. The prototype U box protein, yeast…
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Review
2001
Review
2001
Mechanisms underlying ubiquitination.
C. Pickart
Annual review of biochemistry
2001
Corpus ID: 25577291
The conjugation of ubiquitin to other cellular proteins regulates a broad range of eukaryotic cell functions. The high efficiency…
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Highly Cited
2001
Highly Cited
2001
CHIP is a chaperone‐dependent E3 ligase that ubiquitylates unfolded protein
S. Murata
,
Y. Minami
,
M. Minami
,
T. Chiba
,
Keiji Tanaka
EMBO reports
2001
Corpus ID: 390056
The ubiquitin–proteasome system catalyses the immediate destruction of misfolded or impaired proteins generated in cells, but how…
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Highly Cited
2000
Highly Cited
2000
Mdm2 Is a RING Finger-dependent Ubiquitin Protein Ligase for Itself and p53*
S. Fang
,
J. P. Jensen
,
R. Ludwig
,
K. Vousden
,
A. Weissman
The Journal of Biological Chemistry
2000
Corpus ID: 25630836
Mdm2 has been shown to regulate p53 stability by targeting the p53 protein for proteasomal degradation. We now report that Mdm2…
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Highly Cited
1999
Highly Cited
1999
The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase.
C. Joazeiro
,
S. Wing
,
H. Huang
,
J. Leverson
,
T. Hunter
,
Y. C. Liu
Science
1999
Corpus ID: 8312191
Ubiquitination of receptor protein-tyrosine kinases (RPTKs) terminates signaling by marking active receptors for degradation. c…
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Highly Cited
1995
Highly Cited
1995
A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase.
J. Huibregtse
,
M. Scheffner
,
S. Beaudenon
,
P. Howley
Proceedings of the National Academy of Sciences…
1995
Corpus ID: 12973713
E6-AP is a 100-kDa cellular protein that interacts with the E6 protein of the cancer-associated human papillomavirus types 16 and…
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