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ubiquitin-protein ligase

Known as: Ligases, Ubiquitin-Protein, Ligase, Ubiquitin-Protein, Ligase, E3 
E3 Ubiquitin Ligases are ATP-dependent enzymes that catalyze the formation of a covalent bond between ubiquitous intracellular Ubiquitin proteins and… Expand
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
SHARPIN is a ubiquitin-binding and ubiquitin-like-domain-containing protein which, when mutated in mice, results in immune system… Expand
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Review
2009
Review
2009
The ubiquitylation of proteins is carried out by E1, E2 and E3 (ubiquitin ligase) enzymes, and targets them for degradation or… Expand
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Highly Cited
2005
Highly Cited
2005
The elimination of Mcl-1, an anti-apoptotic Bcl-2 family member, is an early and required step for DNA damage-induced apoptosis… Expand
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Highly Cited
2004
Highly Cited
2004
ABSTRACT The bZIP transcription factor Nrf2 controls a genetic program that protects cells from oxidative damage and maintains… Expand
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Highly Cited
2004
Highly Cited
2004
ABSTRACT Transcription factor Nrf2 is a major regulator of genes encoding phase 2 detoxifying enzymes and antioxidant stress… Expand
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Highly Cited
2004
Highly Cited
2004
ABSTRACT The Nrf2 transcription factor promotes survival following cellular insults that trigger oxidative damage. Nrf2 activity… Expand
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Review
2001
Review
2001
The conjugation of ubiquitin to other cellular proteins regulates a broad range of eukaryotic cell functions. The high efficiency… Expand
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Highly Cited
2000
Highly Cited
2000
Mdm2 has been shown to regulate p53 stability by targeting the p53 protein for proteasomal degradation. We now report that Mdm2… Expand
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Highly Cited
2000
Highly Cited
2000
Ubiquitin-mediated proteolysis regulates the activity of diverse receptor systems. Here, we identify Smurf2, a C2-WW-HECT domain… Expand
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Highly Cited
1999
Highly Cited
1999
Ubiquitination of receptor protein-tyrosine kinases (RPTKs) terminates signaling by marking active receptors for degradation. c… Expand
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