FAQ

ubiquitin-protein ligase

Known as: Ligases, Ubiquitin-Protein, Ligase, Ubiquitin-Protein, Ligase, E3 
E3 Ubiquitin Ligases are ATP-dependent enzymes that catalyze the formation of a covalent bond between ubiquitous intracellular Ubiquitin proteins and… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1989-2018
020040019892018

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39 relations

Narrower (15)

BIRC2 protein, humanBIRC3 protein, humanDNF protein, ArabidopsisFBXW7 protein, human
(More)
BIRC4 protein, humanBRCA1 Associated RING Domain 1 ProteinCullin 2 ProteinCullin 5 Protein
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Broader (2)

Viral Proteinspeptide synthase

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
ubiquitin-protein ligase
physiological aspects
Viral Proteins
chemical synthesis
PARK2 gene
VHL protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Sphingosine-1-phosphate: a Missing Cofactor for the E3 Ubiquitin Ligase Traf2
Tumour-necrosis factor (TNF) receptor-associated factor 2 (TRAF2) is a key component in NF-kappaB signalling triggered by TNF… (More)
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Highly Cited
2008
Highly Cited
2008
Plant Pattern-Recognition Receptor FLS2 Is Directed for Degradation by the Bacterial Ubiquitin Ligase AvrPtoB
BACKGROUND An important layer of active defense in plant immunity is the detection of pathogen-associated molecular patterns… (More)
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Highly Cited
2007
Highly Cited
2007
The E3 Ligase MuRF1 degrades myosin heavy chain protein in dexamethasone-treated skeletal muscle.
Skeletal muscle atrophy occurs as a side effect of treatment with synthetic glucocorticoids such as dexamethasone (DEX) and is a… (More)
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Highly Cited
2004
Highly Cited
2004
Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2.
Transcription factor Nrf2 is a major regulator of genes encoding phase 2 detoxifying enzymes and antioxidant stress proteins in… (More)
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Highly Cited
2004
Highly Cited
2004
The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase.
The Nrf2 transcription factor promotes survival following cellular insults that trigger oxidative damage. Nrf2 activity is… (More)
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Highly Cited
2002
Highly Cited
2002
CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex.
The SCF ubiquitin E3 ligase regulates ubiquitin-dependent proteolysis of many regulatory proteins such as p27(Kip1), IkappaB, and… (More)
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Highly Cited
2001
Highly Cited
2001
Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase.
Cyclin E binds and activates the cyclin-dependent kinase Cdk2 and catalyzes the transition from the G1 phase to the S phase of… (More)
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Highly Cited
2001
Highly Cited
2001
NEDD8 recruits E2-ubiquitin to SCF E3 ligase.
NEDD8/Rub1 is a ubiquitin (Ub)-like post-translational modifier that is covalently linked to cullin (Cul)-family proteins in a… (More)
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Highly Cited
2001
Highly Cited
2001
CHIP is a chaperone-dependent E3 ligase that ubiquitylates unfolded protein.
The ubiquitin-proteasome system catalyses the immediate destruction of misfolded or impaired proteins generated in cells, but how… (More)
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Highly Cited
1999
Highly Cited
1999
Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex.
Mutations of von Hippel-Lindau disease (VHL) tumor-suppressor gene product (pVHL) are found in patients with dominant inherited… (More)
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