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ubiquitin-protein ligase

Known as: Ligases, Ubiquitin-Protein, Ligase, Ubiquitin-Protein, Ligase, E3 
E3 Ubiquitin Ligases are ATP-dependent enzymes that catalyze the formation of a covalent bond between ubiquitous intracellular Ubiquitin proteins and… 
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
SHARPIN is a ubiquitin-binding and ubiquitin-like-domain-containing protein which, when mutated in mice, results in immune system… 
Review
2009
Review
2009
The ubiquitylation of proteins is carried out by E1, E2 and E3 (ubiquitin ligase) enzymes, and targets them for degradation or… 
Highly Cited
2004
Highly Cited
2004
ABSTRACT The bZIP transcription factor Nrf2 controls a genetic program that protects cells from oxidative damage and maintains… 
Highly Cited
2004
Highly Cited
2004
ABSTRACT Transcription factor Nrf2 is a major regulator of genes encoding phase 2 detoxifying enzymes and antioxidant stress… 
Highly Cited
2001
Highly Cited
2001
The U box is a domain of ∼70 amino acids that is present in proteins from yeast to humans. The prototype U box protein, yeast… 
Review
2001
Review
2001
  • C. Pickart
  • Annual review of biochemistry
  • 2001
  • Corpus ID: 25577291
The conjugation of ubiquitin to other cellular proteins regulates a broad range of eukaryotic cell functions. The high efficiency… 
Highly Cited
2001
Highly Cited
2001
The ubiquitin–proteasome system catalyses the immediate destruction of misfolded or impaired proteins generated in cells, but how… 
Highly Cited
2000
Highly Cited
2000
Mdm2 has been shown to regulate p53 stability by targeting the p53 protein for proteasomal degradation. We now report that Mdm2… 
Highly Cited
1999
Highly Cited
1999
Ubiquitination of receptor protein-tyrosine kinases (RPTKs) terminates signaling by marking active receptors for degradation. c… 
Highly Cited
1995
Highly Cited
1995
E6-AP is a 100-kDa cellular protein that interacts with the E6 protein of the cancer-associated human papillomavirus types 16 and…