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ubiquitin-protein ligase

Known as: Ligases, Ubiquitin-Protein, Ligase, Ubiquitin-Protein, Ligase, E3 
E3 Ubiquitin Ligases are ATP-dependent enzymes that catalyze the formation of a covalent bond between ubiquitous intracellular Ubiquitin proteins and… Expand
National Institutes of Health

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BIRC2 protein, humanBIRC3 protein, humanBUL1 protein, S cerevisiaeCOP1 protein, Arabidopsis
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BIRC4 protein, humanEnzyme GeneIn BloodPARK2 gene
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Papers overview

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Highly Cited
2011
Highly Cited
2011
SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis
SHARPIN is a ubiquitin-binding and ubiquitin-like-domain-containing protein which, when mutated in mice, results in immune system… Expand
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Review
2009
Review
2009
Physiological functions of the HECT family of ubiquitin ligases
The ubiquitylation of proteins is carried out by E1, E2 and E3 (ubiquitin ligase) enzymes, and targets them for degradation or… Expand
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Highly Cited
2005
Highly Cited
2005
Mule/ARF-BP1, a BH3-Only E3 Ubiquitin Ligase, Catalyzes the Polyubiquitination of Mcl-1 and Regulates Apoptosis
The elimination of Mcl-1, an anti-apoptotic Bcl-2 family member, is an early and required step for DNA damage-induced apoptosis… Expand
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Highly Cited
2004
Highly Cited
2004
Keap1 Is a Redox-Regulated Substrate Adaptor Protein for a Cul3-Dependent Ubiquitin Ligase Complex
ABSTRACT The bZIP transcription factor Nrf2 controls a genetic program that protects cells from oxidative damage and maintains… Expand
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Highly Cited
2004
Highly Cited
2004
Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase To Regulate Proteasomal Degradation of Nrf2
ABSTRACT Transcription factor Nrf2 is a major regulator of genes encoding phase 2 detoxifying enzymes and antioxidant stress… Expand
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Highly Cited
2004
Highly Cited
2004
The Keap1-BTB Protein Is an Adaptor That Bridges Nrf2 to a Cul3-Based E3 Ligase: Oxidative Stress Sensing by a Cul3-Keap1 Ligase
ABSTRACT The Nrf2 transcription factor promotes survival following cellular insults that trigger oxidative damage. Nrf2 activity… Expand
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Review
2001
Review
2001
Mechanisms underlying ubiquitination.
The conjugation of ubiquitin to other cellular proteins regulates a broad range of eukaryotic cell functions. The high efficiency… Expand
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Highly Cited
2000
Highly Cited
2000
Mdm2 Is a RING Finger-dependent Ubiquitin Protein Ligase for Itself and p53*
Mdm2 has been shown to regulate p53 stability by targeting the p53 protein for proteasomal degradation. We now report that Mdm2… Expand
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Highly Cited
2000
Highly Cited
2000
Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation.
Ubiquitin-mediated proteolysis regulates the activity of diverse receptor systems. Here, we identify Smurf2, a C2-WW-HECT domain… Expand
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Highly Cited
1999
Highly Cited
1999
The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase.
Ubiquitination of receptor protein-tyrosine kinases (RPTKs) terminates signaling by marking active receptors for degradation. c… Expand
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