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FBXW7 gene

Known as: SEL10, C. ELEGANS, HOMOLOG OF, FLJ11071, AGO 
This gene is involved in ubiquitin-dependent proteolysis and regulation of the G1-S cell cycle checkpoint.
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
We analyzed a large cohort of 1160 untreated CLL patients for novel genetic markers (SF3B1, NOTCH1, FBXW7, MYD88, XPO1) in the… Expand
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Highly Cited
2011
Highly Cited
2011
The effective use of targeted therapy is highly dependent on the identification of responder patient populations. Loss of FBW7… Expand
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Highly Cited
2011
Highly Cited
2011
Microtubules have pivotal roles in fundamental cellular processes and are targets of antitubulin chemotherapeutics. Microtubule… Expand
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Highly Cited
2008
Highly Cited
2008
Intrinsically disordered proteins play critical but often poorly understood roles in mediating protein interactions. The… Expand
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Highly Cited
2007
Highly Cited
2007
gamma-secretase inhibitors (GSIs) can block NOTCH receptor signaling in vitro and therefore offer an attractive targeted therapy… Expand
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Highly Cited
1998
Highly Cited
1998
In budding yeast, ubiquitination of the cyclin-dependent kinase (Cdk) inhibitor Sic1 is catalyzed by the E2 ubiquitin conjugating… Expand
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Highly Cited
1997
Highly Cited
1997
Traversal from G1 to S-phase in cycling cells of budding yeast is dependent on the destruction of the S-phase cyclin/CDK… Expand
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Highly Cited
1996
Highly Cited
1996
Regulation of cell cycle progression occurs in part through the targeted degradation of both activating and inhibitory subunits… Expand
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Highly Cited
1986
Highly Cited
1986
Retinal transducin, a guanine nucleotide regulatory protein (referred to as a G protein) that activates a cGMP phosphodiesterase… Expand
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Highly Cited
1971
Highly Cited
1971
Temperature-sensitive mutations occurring in two unlinked complementation groups, cdc4 and cdc8, are recessive and result in a… Expand
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