FBXW7 gene

Known as: SEL10, C. ELEGANS, HOMOLOG OF, FLJ11071, AGO 
This gene is involved in ubiquitin-dependent proteolysis and regulation of the G1-S cell cycle checkpoint.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1983-2017
05101519832017

Papers overview

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2013
2013
The oncogenic transcription factor TAL1/SCL is aberrantly expressed in 60% of cases of human T cell acute lymphoblastic leukemia… (More)
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2012
2012
Fbw7 is the substrate recognition component of the Skp1-Cullin-F-box (SCF)-type E3 ligase complex and a well-characterized tumor… (More)
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2011
2011
The F-box protein FBW7/hCDC4 is a tumor suppressor that acts as the substrate recognition component of an SCF ubiquitin ligase… (More)
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2010
2010
PURPOSE Wilms' tumor (WT), the most common pediatric renal malignancy, is associated with mutations in several well-characterized… (More)
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2009
2009
A molecular target associated with the progression of gastric cancer has not yet been uncovered. FBXW7 is a tumor suppressor gene… (More)
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Highly Cited
2009
Highly Cited
2009
Many somatic genetic abnormalities have been identified in T-cell acute lymphoblastic leukemia (T-ALL) but each individual… (More)
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Highly Cited
2008
Highly Cited
2008
The enzyme mTOR (mammalian target of rapamycin) is a major target for therapeutic intervention to treat many human diseases… (More)
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1998
1998
The CDC34 gene of the yeast Saccharomyces cerevisiae encodes a ubiquitin-conjugating protein that transfers ubiquitin onto… (More)
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Highly Cited
1997
Highly Cited
1997
Mutations that influence lin-12 activity in Caenorhabditis elegans may identify conserved factors that regulate the activity of… (More)
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Highly Cited
1986
Highly Cited
1986
Retinal transducin, a guanine nucleotide regulatory protein (referred to as a G protein) that activates a cGMP phosphodiesterase… (More)
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