FBXW7 wt Allele

Known as: Archipelago Homolog, hAgo, FLJ11071 
Human FBXW7 wild-type allele is located in the vicinity of 4q31.3 and is approximately 91 kb in length. This allele, which encodes F-box/WD-repeat… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1995-2017
05101519952017

Papers overview

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Highly Cited
2011
Highly Cited
2011
This corrects the article DOI: 10.1038/nature09779 
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Highly Cited
2011
Highly Cited
2011
The effective use of targeted therapy is highly dependent on the identification of responder patient populations. Loss of FBW7… (More)
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Highly Cited
2008
Highly Cited
2008
Small RNAs triggering RNA silencing are loaded onto Argonautes and then sequence-specifically guide them to target transcripts… (More)
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Highly Cited
2007
Highly Cited
2007
gamma-secretase inhibitors (GSIs) can block NOTCH receptor signaling in vitro and therefore offer an attractive targeted therapy… (More)
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Highly Cited
2004
Highly Cited
2004
Aneuploidy, an abnormal chromosome number, has been recognized as a hallmark of human cancer for nearly a century; however, the… (More)
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Highly Cited
2004
Highly Cited
2004
Mammalian Fbw7 (also known as Sel-10, hCdc4, or hAgo) is the F-box protein component of an SCF (Skp1-Cul1-F-box protein-Rbx1… (More)
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Highly Cited
2002
Highly Cited
2002
Cyclin-dependent kinase 2 activated by cyclin E is involved in the initiation of DNA replication and other S phase functions… (More)
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Highly Cited
2001
Highly Cited
2001
Cyclin E, one of the activators of the cyclin-dependent kinase Cdk2, is expressed near the G1–S phase transition and is thought… (More)
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Highly Cited
2001
Highly Cited
2001
Notch receptors and their ligands play important roles in both normal animal development and pathogenesis. We show here that the… (More)
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Highly Cited
2001
Highly Cited
2001
The Notch signaling pathway is essential in many cell fate decisions in invertebrates as well as in vertebrates. After ligand… (More)
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