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F5 Leiden Allele

Known as: F5 NP_000121.2:p.Arg534Gln, NM_000130.4:c.1601G>A, F5 NP_000121.2:p.R534Q 
Human F5 Leiden allele is a variant form of the F5 gene that is located in the vicinity of 1q23 and is approximately 75 kb in length. This allele… 
National Institutes of Health

Related topics

Related topics

5 relations
1q23Blood coagulationGuanosine to Adenosine Transition AbnormalityLigand Binding

Papers overview

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Highly Cited
2006
Highly Cited
2006
Fluorescence Visualization Detection of Field Alterations in Tumor Margins of Oral Cancer Patients
Purpose: Genetically altered cells could become widespread across the epithelium of patients with oral cancer, often in… 
Highly Cited
2002
Highly Cited
2002
Prevalence of genetic markers for thrombophilia in recurrent pregnancy loss.
BACKGROUND The genetic predispositions to venous thrombosis such as factor V Leiden (FVL) mutation (Arg 506 Gln), prothrombin… 
Review
2002
Review
2002
Clinical utility of factor V leiden (R506Q) testing for the diagnosis and management of thromboembolic disorders.
OBJECTIVE To review the current state of the art regarding the role of the clinical laboratory in diagnostic testing for the… 
Highly Cited
2001
Highly Cited
2001
Presumed pre‐ or perinatal arterial ischemic stroke: Risk factors and outcomes
A subgroup of children with arterial ischemic stroke in the pre‐ or perinatal period present with delayed diagnosis. We… 
Highly Cited
2001
Highly Cited
2001
Thrombophilic Gene Mutations and Recurrent Spontaneous Abortion: Prothrombin Mutation Increases the Risk in the First Trimester
PROBLEM: Thrombophilic predisposition may be one of the underlying causes of recurrent spontaneous abortions (RSA). We studied… 
Review
2000
Review
2000
Diagnostic Testing for Coagulopathies in Patients With Ischemic Stroke
Background Hypercoagulable states are a recognized, albeit uncommon, etiology of ischemic stroke. It is unclear how often the… 
Highly Cited
1999
Highly Cited
1999
Factor V Leiden, Prothrombin 20210 G → A and the MTHFR C677T Mutations in Childhood Stroke
Summary Ischaemic stroke is a rare occurrence in children and in a proportion of cases the aetiology remains unknown. We have… 
Highly Cited
1999
Highly Cited
1999
Prospective Evaluation of Hemostatic System Activation and Thrombin Potential in Healthy Pregnant Women with and without Factor V Leiden
Summary Normal pregnancy is associated with alterations of the hemostatic system towards a hypercoagulable state and an increased… 
Highly Cited
1998
Highly Cited
1998
Prevalence of the factor V leiden mutation in children and neonates with thromboembolic disease.
Highly Cited
1997
Highly Cited
1997
Prevalence of the factor V Leiden mutation in hepatic and portal vein thrombosis.
BACKGROUND: The factor V Leiden (FVL) mutation has been shown to be the most frequent cause of hereditary thrombophilia. The… 
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