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Fluorescence Visualization Detection of Field Alterations in Tumor Margins of Oral Cancer Patients
These data have, for the first time, shown that direct FV can identify subclinical high-risk fields with cancerous and precancerous changes in the operating room setting. Expand
Loss of Heterozygosity (LOH) Profiles—Validated Risk Predictors for Progression to Oral Cancer
Multicovariate analysis with clinical features showed LOH models to be the most significant predictors of progression in the largest longitudinal study to date of low-grade OPLs from a population-based patient group. Expand
3p14 and 9p21 loss is a simple tool for predicting second oral malignancy at previously treated oral cancer sites.
The identification of 3p and 9p loss in posttreatment lesions could serve as a simple and direct test for stratifying risk of SOM development. Expand
Differential expression of miRNAs in the serum of patients with high-risk oral lesions
Examining the expression profiles of circulating miRNAs in the serum of patients with high‐risk oral lesions and exploring their utility as potential oral cancer biomarkers suggested utility as noninvasive biomarkers for detection of oral cancer or high‐grade lesions. Expand
Toluidine blue staining identifies high-risk primary oral premalignant lesions with poor outcome.
Toluidine blue-positive staining correlated with clinicopathologic risk factors and high-risk molecular risk patterns and a >6-fold elevation in cancer risk was observed for toluidine blue- positive lesions, with positive retention of the dye present in 12 of the 15 lesions that later progressed to cancer. Expand
Direct fluorescence visualization of clinically occult high‐risk oral premalignant disease using a simple hand‐held device
A considerable proportion of oral cancer and precancer is not clinically apparent and could contribute significantly to the late diagnosis and high mortality of oral cancer. A simple method toExpand
Multiple pathways in the FGF signaling network are frequently deregulated by gene amplification in oral dysplasias
Findings identify a critical biological network that is frequently disrupted in high‐risk OPLs, with different specific genes disrupted in different individuals. Expand
Trends in oropharyngeal and oral cavity cancer incidence of human papillomavirus (HPV)‐related and HPV‐unrelated sites in a multicultural population
This study determined incidence rates of OCC and oropharyngeal cancer among South Asian, Chinese, and the general population in British Columbia, Canada. Expand
Biopsy and histopathologic diagnosis of oral premalignant and malignant lesions.
The World Health Organization's description of the architectural and cytologic epithelial changes that characterize dysplasia is detailed, and guidelines for following up patients with premalignant and malignant lesions are provided. Expand
A High Frequency of Allelic Loss in Oral Verrucous Lesions May Explain Malignant Risk
The results showed that VC/VH shared many of the losses present in dysplasia/SCC but differed in two aspects, and the finding of high-risk LOH profiles in VH may partly account for the high-progression risk seen for VH and also has potentially important clinical implications. Expand